Nature Communications (Jul 2020)
Comprehensive identification of mRNA isoforms reveals the diversity of neural cell-surface molecules with roles in retinal development and disease
- Thomas A. Ray,
- Kelly Cochran,
- Chris Kozlowski,
- Jingjing Wang,
- Graham Alexander,
- Martha A. Cady,
- William J. Spencer,
- Philip A. Ruzycki,
- Brian S. Clark,
- Annelies Laeremans,
- Ming-Xiao He,
- Xiaoming Wang,
- Emily Park,
- Ying Hao,
- Alessandro Iannaccone,
- Gary Hu,
- Olivier Fedrigo,
- Nikolai P. Skiba,
- Vadim Y. Arshavsky,
- Jeremy N. Kay
Affiliations
- Thomas A. Ray
- Department of Neurobiology, Duke University School of Medicine
- Kelly Cochran
- Department of Neurobiology, Duke University School of Medicine
- Chris Kozlowski
- Department of Neurobiology, Duke University School of Medicine
- Jingjing Wang
- Department of Neurobiology, Duke University School of Medicine
- Graham Alexander
- Center for Genomic and Computational Biology, Duke University
- Martha A. Cady
- William J. Spencer
- Philip A. Ruzycki
- John F. Hardesty, M.D. Department of Ophthalmology and Visual Sciences, Washington University
- Brian S. Clark
- John F. Hardesty, M.D. Department of Ophthalmology and Visual Sciences, Washington University
- Annelies Laeremans
- Advanced Cell Diagnostics
- Ming-Xiao He
- Advanced Cell Diagnostics
- Xiaoming Wang
- Advanced Cell Diagnostics
- Emily Park
- Advanced Cell Diagnostics
- Ying Hao
- Department of Ophthalmology, Duke University School of Medicine
- Alessandro Iannaccone
- Department of Ophthalmology, Duke University School of Medicine
- Gary Hu
- Department of Neurobiology, Duke University School of Medicine
- Olivier Fedrigo
- Center for Genomic and Computational Biology, Duke University
- Nikolai P. Skiba
- Department of Ophthalmology, Duke University School of Medicine
- Vadim Y. Arshavsky
- Department of Ophthalmology, Duke University School of Medicine
- Jeremy N. Kay
- Department of Neurobiology, Duke University School of Medicine
- DOI
- https://doi.org/10.1038/s41467-020-17009-7
- Journal volume & issue
-
Vol. 11,
no. 1
pp. 1 – 20
Abstract
Here the authors present an approach that can reveal the full complement of mRNA isoforms encoded by individual genes, and they identify a major isoform of the retinal degeneration gene CRB1 which functions at the cell-cell junctions of the outer limiting membrane to promote photoreceptor survival.
