Sphingolipid and Trimethylamine-N-Oxide (TMAO) Levels in Women with Obesity after Combined Physical Training
Camila Fernanda Cunha Brandao,
Michel Krempf,
Flávia Giolo de Carvalho,
Audrey Aguesse,
Márcia Varella Morandi Junqueira-Franco,
Gabriela Batitucci,
Ellen Cristini de Freitas,
Natalia Yumi Noronha,
Guilherme da Silva Rodrigues,
Gizela Pedroso Junqueira,
Diego Alcantara Borba,
Stéphanie Billon-Crossouard,
Mikael Croyal,
Julio Sergio Marchini
Affiliations
Camila Fernanda Cunha Brandao
Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14000-000, São Paulo, Brazil
Michel Krempf
NUN, INRA, The Research Unit of the Thorax Institute, CHU Nantes, UMR 1280, PhAN, IMAD, CRNH-O, F-44000 Nantes, France
Flávia Giolo de Carvalho
School of Physical Education and Sport of Ribeirão Preto, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14000-000, São Paulo, Brazil
Audrey Aguesse
NUN, INRA, The Research Unit of the Thorax Institute, CHU Nantes, UMR 1280, PhAN, IMAD, CRNH-O, F-44000 Nantes, France
Márcia Varella Morandi Junqueira-Franco
Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14000-000, São Paulo, Brazil
Gabriela Batitucci
Department of Food and Nutrition, School of Pharmaceutical Sciences of Araraquara, State University of São Paulo, Rod. Araraquara–Jau Km 1, Araraquara 14800-000, São Paulo, Brazil
Ellen Cristini de Freitas
School of Physical Education and Sport of Ribeirão Preto, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14000-000, São Paulo, Brazil
Natalia Yumi Noronha
Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14000-000, São Paulo, Brazil
Guilherme da Silva Rodrigues
Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14000-000, São Paulo, Brazil
Gizela Pedroso Junqueira
Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14000-000, São Paulo, Brazil
Diego Alcantara Borba
Department of Physical Education, State University of Minas Gerais, Divinópolis 35500-000, Minas Gerais, Brazil
Stéphanie Billon-Crossouard
NUN, INRA, The Research Unit of the Thorax Institute, CHU Nantes, UMR 1280, PhAN, IMAD, CRNH-O, F-44000 Nantes, France
Mikael Croyal
NUN, INRA, The Research Unit of the Thorax Institute, CHU Nantes, UMR 1280, PhAN, IMAD, CRNH-O, F-44000 Nantes, France
Julio Sergio Marchini
Ribeirão Preto Medical School, University of São Paulo, Av. Bandeirantes 3900, Ribeirão Preto 14000-000, São Paulo, Brazil
Obesity causes metabolic changes, such as the development of cardiovascular diseases. Moreover, physical exercise promotes protection against these diseases. Thus, the objective of the present study was to evaluate whether combined physical training can improve the metabolic system of women with obesity, reducing plasma concentrations of trimethylamine N-oxide (TMAO) and sphingolipids, regardless of weight loss. Fourteen obese women (BMI 30–40 kg/m2), aged 20–40 years, sedentary, were submitted to 8 weeks of combined physical training (strength and aerobic exercises). The training was performed three times/week, 55 min/session, at 75–90% maximum heart rate. All participants were evaluated pre- and post-exercise intervention, and their body composition, plasma TMAO, creatinine, lipid profile, and sphingolipid concentrations were recorded. Maximum oxygen consumption (VO2max), Speed lactate threshold 1 (SpeedLT1), and Speed lactate threshold 2 (SpeedLT2) evaluated physical performance. Results: After combined exercise, it did not change body composition, but TMAO, total cholesterol, and sphingolipid concentrations significantly decreased (p p < 0.05). The combined physical exercise could induce cardiovascular risk protection by decreasing TMAO in obese women, parallel to physical performance improvement, independent of weight loss.
