Analytical Cellular Pathology (Jan 2010)
Dual Effects of β3 Integrin Subunit Expression on Human Pancreatic Cancer Models
Abstract
Background: Pancreatic cancer, the fifth leading cause of adult cancer death in Western countries, lacks early detection, and displays significant dissemination ability. Accumulating evidence shows that integrin-mediated cell attachment to the extracellular matrix induces phenotypes and signaling pathways that regulate tumor cell growth and migration.