Data in support of Rap2a GTPase expression, activation and effects in LPS-mediated innate immune response and NF-κB activation
Brener C. Carvalho,
Leonardo C. Oliveira,
Carolina D. Rocha,
Heliana B. Fernandes,
Isadora M. Oliveira,
Felipe B. Leãõ,
Thalita M. Valverde,
Igor M.G. Rego,
Sankar Ghosh,
Aristóbolo M. Silva
Affiliations
Brener C. Carvalho
Laboratory of Inflammatory Genes, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil
Leonardo C. Oliveira
Laboratory of Inflammatory Genes, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil; Department of Microbiology & Immunology, College of Physicians & Surgeons, Columbia University, New York, NY, USA
Carolina D. Rocha
Laboratory of Inflammatory Genes, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil
Heliana B. Fernandes
Laboratory of Inflammatory Genes, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil
Isadora M. Oliveira
Laboratory of Inflammatory Genes, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil
Felipe B. Leãõ
Laboratory of Inflammatory Genes, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil
Thalita M. Valverde
Laboratory of Inflammatory Genes, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil
Igor M.G. Rego
Laboratory of Inflammatory Genes, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil
Sankar Ghosh
Department of Microbiology & Immunology, College of Physicians & Surgeons, Columbia University, New York, NY, USA
Aristóbolo M. Silva
Laboratory of Inflammatory Genes, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil; Corresponding author.
We present here the data to support the understanding of the implication of Rap2a GTPase in LPS-induced innate immune response and NF-κB activation. The data presented are related to molecular tools that were generated, acquired, optimized or validated to investigate Rap2a expression, activation and its effects in mammalian cells including RAW264.7 macrophages and THP-1 monocytes under inflammatory conditions. These data supplement important technical and biological information on immune function of Rap2a in macrophages activated by LPS, recently reported by us (Carvalho et al., 2019) [1].
