The effect of six weeks of increasing endurance training with consumption of L-carnitine on BAX / BCL-2 and oxidative stress indices in the heart tissue of diabetic rats

Abstract

Introduction Diabetes is the most common glandular disease in the world. The purpose of this study was to investigate the effect of six weeks of increasing endurance training with L-carnitine supplementation on Bax / Bcl-2 and oxidative stress indices in the cardiac tissue of diabetic rats. Materials and Methods In this experimental study, 45 male Wistar rats (weighing 20 ± 250 gr) were randomly divided into 6 groups: healthy control, diabetic control, sham, exercise, L carnitine, and exercise and L-carnitine. Rats were diabetic with injected 95 mg nicotinamide by intraperitoneal injection and after 15 minutes of injection, 55 mg STZ per body weight. Rats receiving El Carnitine received daily 100 mg of l-carnitine orally. The aerobic exercise program was started 5 days a week, for six days, with a gradient of zero degree, speed of 10 m and time of 10 minutes in the first week and the final week of gradient it reached 5 degree, speed of 20 m and time of 40 minutes. The variables were measured by ELISA and ASA kits and in the heart tissue. One-way ANOVA and Tukeychr('39')s post hoc test were used to analyze the data using the Shapiro Wylak test. Results The results showed that increasing endurance training and L-carnitine consumption had a significant effect on GPX (P = 0.001), MDA (P = 0.001), and Bax / Bcl2 heart rate (P = 0.001) in diabetic rats. Conclusion It seem The research results confirm the role of aerobic exercise and L-carnitine in improving apoptosis and oxidative stress in type 2 diabetic rats.

Keywords

• increasing endurance training
• oxidative stress
• diabetic rats
• heart