Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas

Yanli Cheng; Zhongtian Shen; Yaqi Gao; Feilong Chen; Huisha Xu; Qinling Mo; Xinlei Chu; Chang-liang Peng; Takese T. McKenzie; Bridgitte E. Palacios; Jian Hu; Hao Zhou; Jiafu Long

doi:10.1038/s41467-022-30447-9

Nature Communications (May 2022)

Phase transition and remodeling complex assembly are important for SS18-SSX oncogenic activity in synovial sarcomas

Yanli Cheng,
Zhongtian Shen,
Yaqi Gao,
Feilong Chen,
Huisha Xu,
Qinling Mo,
Xinlei Chu,
Chang-liang Peng,
Takese T. McKenzie,
Bridgitte E. Palacios,
Jian Hu,
Hao Zhou,
Jiafu Long

Affiliations

Yanli Cheng: State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Science, and College of Life Sciences, Nankai University
Zhongtian Shen: State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Science, and College of Life Sciences, Nankai University
Yaqi Gao: State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Science, and College of Life Sciences, Nankai University
Feilong Chen: State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Science, and College of Life Sciences, Nankai University
Huisha Xu: State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Science, and College of Life Sciences, Nankai University
Qinling Mo: State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Science, and College of Life Sciences, Nankai University
Xinlei Chu: Department of Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital
Chang-liang Peng: Department of Orthopaedics, The Second Hospital, College of Medicine, Shandong University
Takese T. McKenzie: Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences
Bridgitte E. Palacios: Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences
Jian Hu: Department of Cancer Biology, The University of Texas MD Anderson Cancer Center, The University of Texas MD Anderson Cancer Center UT Health Graduate School of Biomedical Sciences
Hao Zhou: State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Science, and College of Life Sciences, Nankai University
Jiafu Long: State Key Laboratory of Medicinal Chemical Biology, Tianjin Key Laboratory of Protein Science, and College of Life Sciences, Nankai University

DOI: https://doi.org/10.1038/s41467-022-30447-9
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 13

Abstract

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Oncoprotein SS18-SSX is a hallmark of synovial sarcoma. Here the authors report phase separation of SS18-SSX and the binding of SS18-SSX to chromatin remodeling complex are important for the transformation activity of the oncoprotein SS18-SSX.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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