Stem Cell Research (May 2022)

Generation of iPS cell line (ICGi040-A) from skin fibroblasts of a patient with ring small supernumerary marker chromosome 4

  • M.M. Gridina,
  • A.R. Nurislamov,
  • J.M. Minina,
  • M.E. Lopatkina,
  • G.V. Drozdov,
  • S.A. Vasilyev,
  • L.I. Minaycheva,
  • E.O. Belyaeva,
  • T.V. Nikitina,
  • A.A. Kashevarova,
  • I.N. Lebedev,
  • T.V. Karamysheva,
  • N.B. Rubtsov,
  • O.L. Serov

Journal volume & issue
Vol. 61
p. 102740

Abstract

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Human induced pluripotent stem cell (iPSC) line, ICGi040-A, was obtained from skin fibroblasts derived from a male patient with mosaic ring small supernumerary marker chromosome 4 (sSMS(4)) and infertility. ICGi040-A cells have karyotype 47,XY,+r(4) in 97% of cells and express a set of pluripotent markers, as well as are able to differentiate in vitro into derivatives of all three embryonic germ layers.