ASSESSMENT OF BIOLOGICAL AGE AND RATE OF AGING OF PATIENTS WITH UNDIFFERENTIATED CONNECTIVE TISSUE DYSPLASIA

Abstract

Aim. Assessment of biological age and the rate of aging of patients with undifferentiated connective tissue dysplasia.Materials and methods. 89 women with 6 or more undifferentiated connective tissue dysplasia phenes and 42 women of the control group with less than 6 undifferentiated connective tissue dysplasia phenes had their biological age determined using the method of V.P. Voitenko. — Tokar A.V. — Chebotarev D.F. (year 1984). External phenotypic signs of undifferentiated connective tissue dysplasia were evaluated during general examination, anthropometry, heart and abdominal organs ultrasonography using «Hitachi F37» device. After calculating biological age, expected biological age was determined using the following formula: eBA = 0,581хCA+17,24 where CA is calendar age. Then the aging rate coefficient was defined (ARC = BA/eBA), which illustrates the number of times the biological age of the examinee is greater or less than expected biological age of her peers.Results. Patients of the main group had a gap (about 8 years) between calendar age and biological age, a positive difference between biological age and expected biological age, as well as aging rate coefficient > 1.Conclusions. Women with undifferentiated connective tissue dysplasia have accelerated aging mechanisms.

Keywords

• biological age
• premature aging
• undifferentiated connective tissue dysplasia