Hypertension in Pregnancy (Oct 2018)

Maternal levels of growth differentiation factor-15 in patients with preeclampsia

  • Ilkbal Temel Yuksel,
  • Begum Aydogan Mathyk,
  • Berna Aslan Cetin,
  • Ugur Turhan,
  • Zihniye Gonca Okumus,
  • Gonca Yetkin Yildirim,
  • Deniz Kanber Acar

DOI
https://doi.org/10.1080/10641955.2018.1524477
Journal volume & issue
Vol. 37, no. 4
pp. 192 – 196

Abstract

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Objective: Growth differentiation factor-15 (GDF-15) is a stress-induced cytokine and related to the prognosis of cardiovascular diseases. Our purpose is to measure the maternal levels of GDF-15 in patients with early-onset preeclampsia (EOPE) and late-onset preeclampsia (LOPE). Methods: This cross-sectional study was conducted including 72 pregnant women, 23 with normal pregnancies and 49 with preeclampsia (26 with EOPE and 23 with LOPE). Maternal serum levels of GDF-15 were measured by using enzyme-linked immunosorbent assay kits. Results: The median serum GDF-15 level was found to be the highest in the EOPE group (EOPE: 441.7 pg/ml). The median serum GDF-15 levels were higher in women with preeclampsia than in the control group (309.7 pg/ml vs. 436.6 pg/ml, p: 0.009). Conclusion: Our findings suggest GDF-15 increased as a response to endothelial injury caused by cytokines triggered by preeclampsia.

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