Alchemy (Sep 2023)

Sintesis Senyawa 4-(Dimetilamino)calkon Menggunakan Microwave-Assisted Organic Synthesis (MAOS) dengan Variasi Konsentrasi NaOH dan Prediksi Profil Farmakokinetik

  • Iin Narwanti,
  • Aisyah Khairani Hidayati

DOI
https://doi.org/10.20961/alchemy.19.2.66542.130-139
Journal volume & issue
Vol. 19, no. 2
pp. 130 – 139

Abstract

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Senyawa calkon dan turunannya mempunyai aktivitas farmakologi dengan aplikasi yang luas, karenya sintesis senyawa tersebut perlu dipelajari. Oleh karena itu, penelitian ini bertujuan untuk mensintesis 4-(dimetilamino)calkon dari dalam suasana basa dengan metode Microwave-Assisted Organic Synthesis (MAOS) dan memprediksi profil farmakokinetiknya. 4-(dimetilamino)calkon direaksikan dengan asetofenon dengan adanya basa NaOH. Sintesis 4-(dimetilamino)calkon dilakukan dengan iradiasi selama 25 detik dengan daya 140 watt. Variasi konsentrasi katalis NaOH yang digunakan adalah 40%, 50%, dan 60%. Rekristalisasi dilakukan dengan menggunakan pelarut etanol. Produk sintesis dikarakterisasi dengan penentuan titik lebur, KLT, spektrofotometri inframerah, spektrometri massa, 1H-NMR dan 13C-NMR. Selanjutnya, profil farmakokinetik 4-(dimetilamino)calkon diprediksi dengan menggunakan web server SwissADME. Hasil penelitian menunjukkan bahwa rata-rata rendemen sintesis 4-(dimetilamino)calkon dengan metode MAOS pada variasi konsentrasi katalis NaOH 40%, 50%, dan 60% berturut-turut adalah 73,4±1,72%; 90,9±0,68% dan 85,1±1,32%. Konsentrasi NaOH 50% menghasilkan rendemen produk sintesis yang paling optimal. Prediksi sifat fisikokimia dan profil farmakokinetik menggunakan SwissADME menunjukkan bahwa senyawa 4-(dimetilamino)calkon memenuhi aturan Lipinski’s Rule of Five dan mempunyai penyerapan gastrointestinal yang baik dan mampu melewati blood brain barrier (BBB). Synthesis of 4-(Dimethylamino)chalcone Compound Using Microwave-Assisted Organic Synthesis (MAOS) with Various NaOH Concentration and Pharmacokinetic Profile Prediction. Chalcones and their derivatives are widely established to have a wide application pharmacological activity; therefore, the synthesis is necessary to study. This study aimed to synthesize 4-dimethylaminochalcone in the presence of a base using Microwave-Assisted Organic Synthesis (MAOS) method and predict its pharmacokinetic profile. 4-(dimethylamino)benzaldehyde was treated with acetophenone in the presence of NaOH with various concentrations (40%, 50%, and 60%). Irradiation was conducted for 25 seconds with a power of 140 watts. Recrystallization was carried out from ethanol to give the expected product. The crude product was characterized by melting point determination, TLC, infrared spectrophotometry, mass spectrometry, 1H-NMR, and 13C-NMR. Furthermore, pharmacokinetic profiles of 4-(dimethylamino)chalcone were predicted using the SwissADME web server. The results showed that the average yield of the synthesized product using the MAOS method with catalyst NaOH 40%, 50%, and 60% was 73.4±1.72%, 90.9±0.68%, and 85.1±1.32%, respectively. The optimal yield was obtained using a 50% concentration of NaOH. The pharmacokinetic profiles of 4-(dimethylamino)chalcone analysis using the SwissADME web server showed that 4-(dimethylamino)chalcone complied with Lipinski's Rule of Five. Furthermore, it might have good gastrointestinal absorption and might be able to cross the blood-brain barrier (BBB).

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