Activity of cytoplasmic NADP-dependent dehydrogenases and cytochromes Р-450 and b5 levels in a rat’s liver under introduction of cobalt and mercury chlorides

Abstract

Influence of the cobalt chloride and mercury chloride on the activity of cytoplasmic NADP-dependent dehydrogenases and cytochromes level in a rat’s liver was studied after 0.5, 2 and 14 hours of introduction. Cobalt chloride and mercury chloride result in decrease of the microsomal cytochromes P-450 and b5 contents in 14 hours. Reduction of the glucose 6-phosphate dehydrogenase and malate dehydrogenase activities in half an hour after cobalt chloride introduction is ascertained. The mercury chloride did not influence on the activity of NADP-dependent dehydrogenases.