Nature Communications (Oct 2020)

DOT1L-mediated murine neuronal differentiation associates with H3K79me2 accumulation and preserves SOX2-enhancer accessibility

  • Francesco Ferrari,
  • Laura Arrigoni,
  • Henriette Franz,
  • Annalisa Izzo,
  • Ludmila Butenko,
  • Eirini Trompouki,
  • Tanja Vogel,
  • Thomas Manke

DOI
https://doi.org/10.1038/s41467-020-19001-7
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 13

Abstract

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Neuronal differentiation requires rearrangement of the transcriptional and chromatin landscapes of neural cells. Here, the authors study in-vitro neuronal differentiation of murine embryonic stem cells (ESCs) to show that this process is modulated by DOT1L activity, which regulates H3K79me2 accumulation, and preserves accessibility of SOX2-bound enhancers.