The Role of Peroxisome Proliferator-Activated Receptors in Polycystic Ovary Syndrome

Iason Psilopatis; Kleio Vrettou; Eleni Nousiopoulou; Kostas Palamaris; Stamatios Theocharis

doi:10.3390/jcm12082912

Journal of Clinical Medicine (Apr 2023)

The Role of Peroxisome Proliferator-Activated Receptors in Polycystic Ovary Syndrome

Iason Psilopatis,
Kleio Vrettou,
Eleni Nousiopoulou,
Kostas Palamaris,
Stamatios Theocharis

Affiliations

Iason Psilopatis: Department of Gynecology, Charité—Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin and Humboldt—Universität zu Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
Kleio Vrettou: First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Bld 10, Goudi, 11527 Athens, Greece
Eleni Nousiopoulou: First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Bld 10, Goudi, 11527 Athens, Greece
Kostas Palamaris: First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Bld 10, Goudi, 11527 Athens, Greece
Stamatios Theocharis: First Department of Pathology, Medical School, National and Kapodistrian University of Athens, 75 Mikras Asias Street, Bld 10, Goudi, 11527 Athens, Greece

DOI: https://doi.org/10.3390/jcm12082912
Journal volume & issue: Vol. 12, no. 8
p. 2912

Abstract

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Polycystic ovary syndrome (PCOS) constitutes the most common endocrine disorder in women of reproductive age. Patients usually suffer from severe menstrual irregularities, skin conditions, and insulin resistance-associated health conditions. Peroxisome proliferator-activated receptors (PPARs) are nuclear receptor proteins that regulate gene expression. In order to investigate the role of PPARs in the pathophysiology of PCOS, we conducted a literature review using the MEDLINE and LIVIVO databases and were able to identify 74 relevant studies published between 2003 and 2023. Different study groups reached contradictory conclusions in terms of PPAR expression in PCOS. Interestingly, numerous natural agents were found to represent a novel, potent anti-PCOS treatment alternatives. In conclusion, PPARs seem to play a significant role in PCOS.

Published in Journal of Clinical Medicine

ISSN: 2077-0383 (Online)
Publisher: MDPI AG
Country of publisher: Switzerland
LCC subjects: Medicine
Website: http://www.mdpi.com/journal/jcm

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