Increased Lipid Peroxidation in Cerebrospinal Fluid and Plasma from Patients with Creutzfeldt–Jakob Disease

Sönke Arlt; Anatol Kontush; Inga Zerr; Carsten Buhmann; Christian Jacobi; Andreas Schröter; Sigrid Poser; Ulrike Beisiegel

Neurobiology of Disease (Jul 2002)

Increased Lipid Peroxidation in Cerebrospinal Fluid and Plasma from Patients with Creutzfeldt–Jakob Disease

Sönke Arlt,
Anatol Kontush,
Inga Zerr,
Carsten Buhmann,
Christian Jacobi,
Andreas Schröter,
Sigrid Poser,
Ulrike Beisiegel

Affiliations

Sönke Arlt: Institute for Medical Biochemistry and Molecular Biology, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Neurological Clinic, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Neurological Clinic, University of Göttingen, Göttingen, Germany
Anatol Kontush: Institute for Medical Biochemistry and Molecular Biology, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Neurological Clinic, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Neurological Clinic, University of Göttingen, Göttingen, Germany
Inga Zerr: Institute for Medical Biochemistry and Molecular Biology, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Neurological Clinic, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Neurological Clinic, University of Göttingen, Göttingen, Germany
Carsten Buhmann: Institute for Medical Biochemistry and Molecular Biology, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Neurological Clinic, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Neurological Clinic, University of Göttingen, Göttingen, Germany
Christian Jacobi: Institute for Medical Biochemistry and Molecular Biology, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Neurological Clinic, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Neurological Clinic, University of Göttingen, Göttingen, Germany
Andreas Schröter: Institute for Medical Biochemistry and Molecular Biology, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Neurological Clinic, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Neurological Clinic, University of Göttingen, Göttingen, Germany
Sigrid Poser: Institute for Medical Biochemistry and Molecular Biology, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Neurological Clinic, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Neurological Clinic, University of Göttingen, Göttingen, Germany
Ulrike Beisiegel: Institute for Medical Biochemistry and Molecular Biology, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Neurological Clinic, University Hospital Hamburg-Eppendorf, Hamburg, Germany; Neurological Clinic, University of Göttingen, Göttingen, Germany

Journal volume & issue: Vol. 10, no. 2
pp. 150 – 156

Abstract

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Oxidative pathomechanisms play an important role in neurodegenerative diseases like Alzheimer's disease (AD). It has been shown that lipid peroxidation in cerebrospinal fluid (CSF) and plasma is increased in AD. To assess the role of oxidative stress in Creutzfeldt–Jakob disease (CJD), we investigated the oxidizability of lipids, the lipid composition and the levels of the antioxidants ascorbate and α-tocopherol in CSF and plasma of 15 CJD patients and 12 neurologically healthy controls. CSF and plasma lipid peroxidation was increased in CJD patients and polyunsaturated fatty acids were reduced in CSF of these patients. Ascorbate levels were lower in CSF and plasma of CJD patients, while α-tocopherol was found to be decreased in CSF but not in plasma. These results support the hypothesis that oxidative mechanisms are involved in the pathogenesis of CJD and provide a rationale for the use of antioxidants in the therapy of this disease.

Published in Neurobiology of Disease

ISSN: 0969-9961 (Print); 1095-953X (Online)
Publisher: Elsevier
Country of publisher: United States
LCC subjects: Medicine: Internal medicine: Neurosciences. Biological psychiatry. Neuropsychiatry
Website: https://www.journals.elsevier.com/neurobiology-of-disease

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