Communications Biology (May 2022)
Histone macroH2A1 is a stronger regulator of hippocampal transcription and memory than macroH2A2 in mice
- Gurdeep Singh,
- Gilda Stefanelli,
- Klotilda Narkaj,
- Mark A. Brimble,
- Samantha D. Creighton,
- Timothy A. B. McLean,
- Meaghan Hall,
- Krista A. Mitchnick,
- Jacqueline Zakaria,
- Thanh Phung,
- Anas Reda,
- Amanda M. Leonetti,
- Ashley Monks,
- Lara Ianov,
- Boyer D. Winters,
- Brandon J. Walters,
- Andrew M. Davidoff,
- Jennifer A. Mitchell,
- Iva B. Zovkic
Affiliations
- Gurdeep Singh
- Department of Cell & Systems Biology, University of Toronto
- Gilda Stefanelli
- Department of Psychology, University of Toronto Mississauga
- Klotilda Narkaj
- Department of Cell & Systems Biology, University of Toronto
- Mark A. Brimble
- Department of Surgery, St. Jude Children’s Research Hospital
- Samantha D. Creighton
- Department of Psychology, University of Toronto Mississauga
- Timothy A. B. McLean
- Department of Cell & Systems Biology, University of Toronto
- Meaghan Hall
- Department of Psychology, University of Toronto Mississauga
- Krista A. Mitchnick
- Department of Psychology, York University
- Jacqueline Zakaria
- Department of Psychology, University of Toronto Mississauga
- Thanh Phung
- Department of Cell & Systems Biology, University of Toronto
- Anas Reda
- Department of Cell & Systems Biology, University of Toronto
- Amanda M. Leonetti
- Department of Cell & Systems Biology, University of Toronto
- Ashley Monks
- Department of Psychology, University of Toronto Mississauga
- Lara Ianov
- Civitan International Research Center, University of Alabama at Birmingham
- Boyer D. Winters
- Department of Psychology, University of Guelph
- Brandon J. Walters
- Department of Biology, University of Toronto Mississauga
- Andrew M. Davidoff
- Department of Psychology, University of Toronto Mississauga
- Jennifer A. Mitchell
- Department of Cell & Systems Biology, University of Toronto
- Iva B. Zovkic
- Department of Psychology, University of Toronto Mississauga
- DOI
- https://doi.org/10.1038/s42003-022-03435-4
- Journal volume & issue
-
Vol. 5,
no. 1
pp. 1 – 14
Abstract
The structurally-unique histone variant, mH2A1, influences learning and memory in mice to a greater extent than a similar variant, mH2A2.
