Cell Cycle Regulators and Lineage-Specific Therapeutic Targets for Cushing Disease

Takako Araki; Ning-Ai Liu

doi:10.3389/fendo.2018.00444

Frontiers in Endocrinology (Aug 2018)

Cell Cycle Regulators and Lineage-Specific Therapeutic Targets for Cushing Disease

Takako Araki,
Ning-Ai Liu

Affiliations

Takako Araki: Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Minnesota, Minneapolis, MN, United States
Ning-Ai Liu: Department of Medicine, Pituitary Center, Cedars-Sinai Medical Center, Los Angeles, CA, United States

DOI: https://doi.org/10.3389/fendo.2018.00444
Journal volume & issue: Vol. 9

Abstract

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Cell cycle proteins are critical to pituitary development, but their contribution to lineage-specific tumorigenesis has not been well-elucidated. Emerging evidence from in vitro human tumor analysis and transgenic mouse models indicates that G1/S-related cell cycle proteins, particularly cyclin E, p27, Rb, and E2F1, drive molecular mechanisms that underlie corticotroph-specific differentiation and development of Cushing disease. The aim of this review is to summarize the literature and discuss the complex role of cell cycle regulation in Cushing disease, with a focus on identifying potential targets for therapeutic intervention in patients with these tumors.

Published in Frontiers in Endocrinology

ISSN: 1664-2392 (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the endocrine glands. Clinical endocrinology
Website: https://www.frontiersin.org/journals/endocrinology

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Abstract

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