Au Ordered Array Substrate for Rapid Detection and Precise Identification of Etomidate in E-Liquid Through Surface-Enhanced Raman Spectroscopy
Yan Mo,
Xiaoping Zhang,
Ke Zou,
Wen Xing,
Xiayang Hou,
Yu Zeng,
Yugang Cai,
Ruixiang Xu,
Hongwen Zhang,
Weiping Cai
Affiliations
Yan Mo
Intelligent Policing Key Laboratory of Sichuan Province, Sichuan Police College, Luzhou 646000, China
Xiaoping Zhang
Anhui Xianghe Environmental Testing Co., Ltd., Huaibei 235100, China
Ke Zou
Anhui Xianghe Environmental Testing Co., Ltd., Huaibei 235100, China
Wen Xing
Anhui Xianghe Environmental Testing Co., Ltd., Huaibei 235100, China
Xiayang Hou
Intelligent Policing Key Laboratory of Sichuan Province, Sichuan Police College, Luzhou 646000, China
Yu Zeng
Department of Intelligent Manufacturing and Automotive Engineering, Luzhou Vocational & Technical College, Luzhou 646000, China
Yugang Cai
Luzhou Public Security Bureau, Luzhou 646000, China
Ruixiang Xu
Intelligent Policing Key Laboratory of Sichuan Province, Sichuan Police College, Luzhou 646000, China
Hongwen Zhang
Key Laboratory of Materials Physics, Anhui Key Laboratory of Nanomaterials and Nanotechnology, Institute of Solid State Physics, HFIPS, Chinese Academy of Sciences, Hefei 230031, China
Weiping Cai
Key Laboratory of Materials Physics, Anhui Key Laboratory of Nanomaterials and Nanotechnology, Institute of Solid State Physics, HFIPS, Chinese Academy of Sciences, Hefei 230031, China
Etomidate (ET), a medical anesthetic, is increasingly being incorporated into e-liquids for consumption and abuse as a new psychoactive substance (NPS), leading to significant social issues. In this work, large-area Au micro- and nano-structured ordered arrays were engineered as surface-enhanced Raman spectroscopy (SERS) substrates for fast detection and precise identification of ET and its metabolites. This ordered array, characterized by abundant electromagnetic enhancement hotspots and structural uniformity, imparts unique properties to the SERS substrate, including ultra-sensitivity, spectral signal reproducibility, and precise quantitative capabilities. Furthermore, it effectively mitigates interference from the complex matrix of e-liquids, facilitating the rapid detection of trace amounts of ET molecules. This SERS rapid detection technology can act as a preliminary screening method for gold-standard spectroscopic analysis, facilitating the on-site rapid screening of suspicious samples and thereby enabling efficient detection and precise verification.
