Evaluation of Neutrophil to Lymphocyte Ratio (NLR) as a Marker to Determine the Extent of Disease in Patients with Preeclampsia

Abstract

Background & objectives: Early diagnosis of preeclampsia and its severity in pregnant women is greatly important for controlling this disease and preventing subsequent dangers for mother and the fetus. Current study is conducted to assess neutrophil-lymphocyte ratio (NLR) as a determining factor for the severity of the disease in patients with preeclampsia referring to Sabalan hospital, Ardabil. Methods: This was a case control study on 50 pregnant women with severe preeclampsia (group 1), 50 pregnant women with mild preeclampsia (group 2), and 50 healthy pregnant women (group 3). The groups were homogenized for basic variants including age, gestational age, mean BMI, gravid and parity. Required information including age, gestational week, BMI, gravid, parity, 24-hour urine protein, systolic and diastolic blood pressure, and NLR were obtained and analyzed. Results: The NLR was significantly higher in women with severe preeclampsia compared with mild preeclampsia (p=0.031) and healthy women (p<0.001). NLR did not show difference between mild preeclampsia and healthy women (p=0.209). Significant positive correlation was also observed between NLR and proteinuria (p<0.0001, r=0.558), systolic blood pressure (p=0.0026, r=0.244), and diastolic blood pressure (p=0.0028, r=0.242). Conclusion: This study showed that maternal NLR can be used as a marker for preeclampsia severity.

Keywords

• Neutrophil
• Lymphocyte
• Pre-eclampsia
• Illness severity
• Pregnant Women