Efficient allelic-drive in Drosophila

Annabel Guichard; Tisha Haque; Marketta Bobik; Xiang-Ru S. Xu; Carissa Klanseck; Raja Babu Singh Kushwah; Mateus Berni; Bhagyashree Kaduskar; Valentino M. Gantz; Ethan Bier

doi:10.1038/s41467-019-09694-w

Nature Communications (Apr 2019)

Efficient allelic-drive in Drosophila

Annabel Guichard,
Tisha Haque,
Marketta Bobik,
Xiang-Ru S. Xu,
Carissa Klanseck,
Raja Babu Singh Kushwah,
Mateus Berni,
Bhagyashree Kaduskar,
Valentino M. Gantz,
Ethan Bier

Affiliations

Annabel Guichard: Section of Cell and Developmental Biology, University of California, San Diego
Tisha Haque: Section of Cell and Developmental Biology, University of California, San Diego
Marketta Bobik: Section of Cell and Developmental Biology, University of California, San Diego
Xiang-Ru S. Xu: Section of Cell and Developmental Biology, University of California, San Diego
Carissa Klanseck: Section of Cell and Developmental Biology, University of California, San Diego
Raja Babu Singh Kushwah: Section of Cell and Developmental Biology, University of California, San Diego
Mateus Berni: Instituto de Ciências Biomédicas (ICB), Universidade Federal do Rio de Janeiro
Bhagyashree Kaduskar: Section of Cell and Developmental Biology, University of California, San Diego
Valentino M. Gantz: Section of Cell and Developmental Biology, University of California, San Diego
Ethan Bier: Section of Cell and Developmental Biology, University of California, San Diego

DOI: https://doi.org/10.1038/s41467-019-09694-w
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 10

Abstract

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Gene-drives use CRISPR-Cas9 to be transmitted in a super-Mendelian fashion. Here the authors develop an allelic-drive for selective inheritance of a desired allele.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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