Comptes Rendus Biologies (Apr 2021)
FHL1 is a key player of chikungunya virus tropism and pathogenesis
- Meertens, Laurent,
- Hafirassou, Mohamed Lamine,
- Couderc, Thérèse,
- Bonnet-Madin, Lucie,
- Kril, Vasiliya,
- Kümmerer, Beate M.,
- Labeau, Athena,
- Brugier, Alexis,
- Simon-Loriere, Etienne,
- Burlaud-Gaillard, Julien,
- Doyen, Cécile,
- Pezzi, Laura,
- Goupil, Thibaud,
- Rafasse, Sophia,
- Vidalain, Pierre-Olivier,
- Legout, Anne Bertrand,
- Gueneau, Lucie,
- Juntas-Morales, Raul,
- Yaou, Rabah Ben,
- Bonne, Gisèle,
- de Lamballerie, Xavier,
- Benkirane, Monsef,
- Roingeard, Philippe,
- Delaugerre, Constance,
- Lecuit, Marc,
- Amara, Ali
Affiliations
- Meertens, Laurent
- Cell Biology of Virus Infection Team, Inserm U944, CNRS UMR 7212, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis, 75010 Paris, France
- Hafirassou, Mohamed Lamine
- Cell Biology of Virus Infection Team, Inserm U944, CNRS UMR 7212, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis, 75010 Paris, France
- Couderc, Thérèse
- Biology of Infection Unit, Institut Pasteur, Inserm U1117, Paris, France
- Bonnet-Madin, Lucie
- Cell Biology of Virus Infection Team, Inserm U944, CNRS UMR 7212, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis, 75010 Paris, France
- Kril, Vasiliya
- Cell Biology of Virus Infection Team, Inserm U944, CNRS UMR 7212, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis, 75010 Paris, France
- Kümmerer, Beate M.
- Institute of Virology, University of Bonn Medical Centre, Bonn, Germany
- Labeau, Athena
- Cell Biology of Virus Infection Team, Inserm U944, CNRS UMR 7212, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis, 75010 Paris, France
- Brugier, Alexis
- Cell Biology of Virus Infection Team, Inserm U944, CNRS UMR 7212, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis, 75010 Paris, France
- Simon-Loriere, Etienne
- G5 Evolutionary Genomics of RNA Viruses, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris, France
- Burlaud-Gaillard, Julien
- Inserm U1259 MAVIVH et Plateforme IBiSA de Microscopie Electronique, Université de Tours, France
- Doyen, Cécile
- Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, CNRS-Université de Montpellier, 34000 Montpellier, France
- Pezzi, Laura
- Unité des Virus Émergents, Aix-Marseille Univ–IRD190–Inserm 1207, EFS-IRBA, 13005 Marseille cedex 05, France
- Goupil, Thibaud
- Biology of Infection Unit, Institut Pasteur, Inserm U1117, Paris, France
- Rafasse, Sophia
- Biology of Infection Unit, Institut Pasteur, Inserm U1117, Paris, France
- Vidalain, Pierre-Olivier
- Equipe Chimie & Biologie, Modélisation et Immunologie pour la Thérapie, Université Paris Descartes, CNRS UMR 8601, Paris, France
- Legout, Anne Bertrand
- Sorbonne Université, INSERM UMRS974, Center of Research in Myology, F-75013 Paris, France
- Gueneau, Lucie
- Sorbonne Université, INSERM UMRS974, Center of Research in Myology, F-75013 Paris, France
- Juntas-Morales, Raul
- Département de Neurologie, Centre Hospitalier Universitaire de Montpellier, Montpellier, France
- Yaou, Rabah Ben
- Sorbonne Université, INSERM UMRS974, Center of Research in Myology, F-75013 Paris, France
- Bonne, Gisèle
- Sorbonne Université, INSERM UMRS974, Center of Research in Myology, F-75013 Paris, France
- de Lamballerie, Xavier
- Unité des Virus Émergents, Aix-Marseille Univ–IRD190–Inserm 1207, EFS-IRBA, 13005 Marseille cedex 05, France
- Benkirane, Monsef
- Institut de Génétique Humaine, Laboratoire de Virologie Moléculaire, CNRS-Université de Montpellier, 34000 Montpellier, France
- Roingeard, Philippe
- Inserm U1259 MAVIVH et Plateforme IBiSA de Microscopie Electronique, Université de Tours, France
- Delaugerre, Constance
- Cell Biology of Virus Infection Team, Inserm U944, CNRS UMR 7212, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis, 75010 Paris, France; Laboratoire de Virologie et Département des Maladies Infectieuses, Hôpital Saint-Louis, APHP, 75010 Paris, France
- Lecuit, Marc
- Biology of Infection Unit, Institut Pasteur, Inserm U1117, Paris, France; Université de Paris, Department of Infectious Diseases and Tropical Medicine, Necker-Enfants Malades University Hospital, APHP, Institut Imagine, Paris, France
- Amara, Ali
- Cell Biology of Virus Infection Team, Inserm U944, CNRS UMR 7212, Institut de Recherche Saint-Louis, Université de Paris, Hôpital Saint-Louis, 75010 Paris, France
- DOI
- https://doi.org/10.5802/crbiol.40
- Journal volume & issue
-
Vol. 343,
no. 4
pp. 79 – 89
Abstract
Chikungunya is an infectious disease caused by the chikungunya virus (CHIKV), an alphavirus transmitted to humans by Aedes mosquitoes, and for which there is no licensed vaccine nor antiviral treatments. By using a loss-of-function genetic screen, we have recently identified the FHL1 protein as an essential host factor for CHIKV tropism and pathogenesis. FHL1 is highly expressed in muscles cells and fibroblasts, the main CHIKV-target cells. FHL1 interacts with the viral protein nsP3 and plays a critical role in CHIKV genome amplification. Experiments in vivo performed in FHL1-deficient mice have shown that these animals are resistant to infection and do not develop muscular lesions. Altogether these observations, published in the journal Nature [1], show that FHL1 is a key host factor for CHIKV pathogenesis and identify the interaction between FHL1 and nsP3 as a promising target for the development of new antiviral strategies.
Keywords
