npj Regenerative Medicine (Jun 2021)

Senolytics improve bone forming potential of bone marrow mesenchymal stem cells from aged mice

  • Yueying Zhou,
  • Xiaonan Xin,
  • Lichao Wang,
  • Binsheng Wang,
  • Li Chen,
  • Ousheng Liu,
  • David W. Rowe,
  • Ming Xu

DOI
https://doi.org/10.1038/s41536-021-00145-z
Journal volume & issue
Vol. 6, no. 1
pp. 1 – 5

Abstract

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Abstract The osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) declines dramatically with aging. By using a calvarial defect model, we showed that a senolytic cocktail (dasatinib+quercetin; D + Q) improved osteogenic capacity of aged BMSC both in vitro and in vivo. The study presented a model to assess strategies to improve bone-forming potential on aged BMSCs. D + Q might hold promise for improving BMSC function in aged populations.