Nature Communications (Feb 2019)

The short-chain fatty acid pentanoate suppresses autoimmunity by modulating the metabolic-epigenetic crosstalk in lymphocytes

  • Maik Luu,
  • Sabine Pautz,
  • Vanessa Kohl,
  • Rajeev Singh,
  • Rossana Romero,
  • Sébastien Lucas,
  • Jörg Hofmann,
  • Hartmann Raifer,
  • Niyati Vachharajani,
  • Lucia Campos Carrascosa,
  • Boris Lamp,
  • Andrea Nist,
  • Thorsten Stiewe,
  • Yoav Shaul,
  • Till Adhikary,
  • Mario M. Zaiss,
  • Matthias Lauth,
  • Ulrich Steinhoff,
  • Alexander Visekruna

DOI
https://doi.org/10.1038/s41467-019-08711-2
Journal volume & issue
Vol. 10, no. 1
pp. 1 – 12

Abstract

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Short-chain fatty acids (SCFAs) have immunomodulatory effects, but the underlying mechanisms are still unclear. Here the authors show that a SCFA, pentanoate, suppresses autoimmune inflammation in mouse models of colitis and multiple sclerosis via epigenetic modulation of immune cell metabolic and functional pathways.