THE INTENSITY OF SYSTEMIC INFLAMMATION RESPONSE IN THOSE SUFFERING FROM HIV-ASSOCIATED TUBERCULOSIS

Abstract

238 tuberculosis cases with concurrent HIV infection were examined. The age of patients varied from 24 to 57 years old. Men made 189 (79.4%), and women 49 (20.6%). The CD4 count in the examined patients varied from 0 to 1.216 × 109/L. The intensity of systematic inflammatory response was evaluated as per the rates of acute phase reactants: С-reactive protein (СRP), α1-antitrypsin (α1-АТ), haptoglobin (HG) and fibrinogen (F). It was found out that tuberculosis patients with concurrent HIV infection demonstrated confidently increased levels of C-reactive protein, α1-antitrypsin, and haptoglobin, which was the evidence of systemic inflammatory response. However, the increase of fibrinogen level was not typical of tuberculosis patients with concurrent HIV infection. The comparative analysis proved that the intensity of systemic inflammatory response was increasing simultaneously with the severity of the immune deficiency, and the growth of acute phase reactants' level with a parallel reduction of CD4 count was the evidence of the above. C-reactive protein and α1-antitrypsin were the most informative markers of systemic inflammatory response intensity in tuberculosis patients with concurrent HIV infection.

Keywords

• туберкулез
• вич-инфекция
• белки острой фазы
• системный воспалительный ответ