Research progress of autophagy regulated by mTOR in diabetic complications

Abstract

In the state of diabetes, dysfunctional autophagy may lead to pathological changes of multiple organs. The mTOR-mediated autophagy is involved in the regulation of diabetic complications and concomitant diseases, such as diabetic nephropathy, non-alcoholic fatty liver, diabetic heart disease, diabetic retinopathy, diabetic peripheral neuropathy and so on. The study on the mechanism of diabetic autophagy will help to find new therapeutic targets and better methods to prevent and treat diabetic complications.

Keywords

• mtor|autophagy|new hypoglycemic drugs|diabetic complications