Extracellular Vesicles as Biomarkers in Cardiovascular Disease; Chances and Risks

Annemiek Dickhout; Rory R. Koenen; Rory R. Koenen

doi:10.3389/fcvm.2018.00113

Frontiers in Cardiovascular Medicine (Aug 2018)

Extracellular Vesicles as Biomarkers in Cardiovascular Disease; Chances and Risks

Annemiek Dickhout,
Rory R. Koenen,
Rory R. Koenen

Affiliations

Annemiek Dickhout: Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht, Netherlands
Rory R. Koenen: Department of Biochemistry, Cardiovascular Research Institute Maastricht, Maastricht, Netherlands
Rory R. Koenen: Institute for Cardiovascular Prevention, Ludwig-Maximilians-Universität München, Munich, Germany

DOI: https://doi.org/10.3389/fcvm.2018.00113
Journal volume & issue: Vol. 5

Abstract

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The field of extracellular vesicles (EV) is rapidly expanding, also within cardiovascular diseases. Besides their exciting roles in cell-to-cell communication, EV have the potential to serve as excellent biomarkers, since their counts, content, and origin might provide useful information about the pathophysiology of cardiovascular disorders. Various studies have already indicated associations of EV counts and content with cardiovascular diseases. However, EV research is complicated by several factors, most notably the small size of EV. In this review, the advantages and drawbacks of EV-related methods and applications as biomarkers are highlighted.

Published in Frontiers in Cardiovascular Medicine

ISSN: 2297-055X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Internal medicine: Specialties of internal medicine: Diseases of the circulatory (Cardiovascular) system
Website: https://www.frontiersin.org/journals/cardiovascular-medicine

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Abstract

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