Three cases of congenital self‐healing Langerhans cell histiocytosis with BRAF‐V600E mutation

Abstract

Abstract Congenital self‐healing Langerhans cell histiocytosis (CSHLCH) is a rare variant of Langerhans cell histiocytosis characterised by the presence of skin lesions in the neonate and spontaneous self‐healing after a variable period of time. We report three cases of CSHLCH with BRAF‐V600E mutation and high Ki‐67 proliferative activity.

Keywords

• BRAF protein
• congenital self‐healing Langerhans cell histiocytosis
• histiocytosis
• Langerhans cell histiocytosis
• mitogen‐activated protein kinases (MAPKs)