BMJ Open (Feb 2021)
Protocol for a gallbladder cancer registry study in China: the Chinese Research Group of Gallbladder Cancer (CRGGC) study
- Xun Li,
- Bo Yang,
- Hong Cao,
- Tai Ren,
- Yongsheng Li,
- Yajun Geng,
- Ziyu Shao,
- Xiangsong Wu,
- Xu-An Wang,
- Wenguang Wu,
- Yijun Shu,
- Runfa Bao,
- Ping Dong,
- Xueyi Dang,
- Changjun Liu,
- Defei Hong,
- Xuewen Zhang,
- Junmin Xu,
- Jianguang Jia,
- Chaoliu Dai,
- Jingyu Cao,
- Feng Tao,
- Zaiyang Zhang,
- Huihan Jin,
- Hongyu Cai,
- Zhewei Fei,
- Jianfeng Gu,
- Xuedong Feng,
- Linhui Zheng,
- Chunfu Zhu,
- Kunhua Wang,
- Xiaoyong Li,
- Chong Jin,
- Yeben Qian,
- Yunfu Cui,
- Yuzhen Xu,
- Yawei Hua,
- Chuanlei Wang,
- Qiyun Li,
- Jiansheng Liu,
- Mingzhang Li,
- Yudong Qiu,
- Buqiang Wu,
- Jinfang Zheng,
- Haihong Zhu,
- Kejun Hua,
- Maolin Yan,
- Hong Zang,
- Xiaoming Ma,
- Jian Hong
Affiliations
- Xun Li
- Navigate BiPharma
- Bo Yang
- Research & Development, 3D Medicines Inc, Shanghai, China
- Hong Cao
- Department of Microbiology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health, Southern Medical University, Guangzhou, Guangdong, China
- Tai Ren
- Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
- Yongsheng Li
- Shanghai Key Laboratory of Biliary Tract Disease Research, Shanghai, China
- Yajun Geng
- Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
- Ziyu Shao
- Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
- Xiangsong Wu
- Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
- Xu-An Wang
- Shanghai Key Laboratory of Biliary Tract Disease Research, Shanghai, China
- Wenguang Wu
- Shanghai Key Laboratory of Biliary Tract Disease Research, Shanghai, China
- Yijun Shu
- Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
- Runfa Bao
- Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
- Ping Dong
- Department of General Surgery, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai, China
- Xueyi Dang
- Department of General Surgery, Shanxi Provincial Cancer Hospital, Taiyuan, Shanxi, China
- Changjun Liu
- Department of Hepatobiliary Surgery, People's Hospital of Hunan Province, Changsha, Hunan, China
- Defei Hong
- Department of HPB Surgery, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
- Xuewen Zhang
- Department of HPB Surgery, The Second Hospital of Jilin University, Changchun, Jilin, China
- Junmin Xu
- Department of General Surgery, Shanghai General Hospital, Shanghai, China
- Jianguang Jia
- Department of Surgical Oncology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China
- Chaoliu Dai
- Department of Hepatobiliary Surgery, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China
- Jingyu Cao
- Department of HPB Surgery, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China
- Feng Tao
- Department of GI Surgery, Shaoxing People's Hospital, Shaoxing, Zhejiang, China
- Zaiyang Zhang
- Department of General Surgery, Shaoxing Second Hospital, Shaoxing, Zhejiang, China
- Huihan Jin
- Department of Hepatobiliary Surgery, Wuxi Second People's Hospital, Wuxi, Jiangsu, China
- Hongyu Cai
- Department of Hepatobiliary Surgery, Nantong Tumor Hospital, Nantong, Jiangsu, China
- Zhewei Fei
- Department of General Surgery, Shanghai Jiaotong University School of Medicine Xinhua Hospital Chongming Branch, Shanghai, China
- Jianfeng Gu
- Department of General Surgery, Changshu No. 1 People's Hospital, Changshu, Jiangsu, China
- Xuedong Feng
- Department of General Surgery, Tongliao City Hospital, Inner Mongolia, Tongliao, China
- Linhui Zheng
- Department of General Surgery, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China
- Chunfu Zhu
- Department of HPB Surgery, Changzhou No. 2 People’s Hospital, Changzhou, Jiangsu, China
- Kunhua Wang
- Department of General Surgery, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China
- Xiaoyong Li
- Department of HPB Surgery, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
- Chong Jin
- Department of General Surgery, Taizhou Municipal Hospital, Taizhou, Zhejiang, China
- Yeben Qian
- Department of HPB Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China
- Yunfu Cui
- Department of Pancreatobiliary Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China
- Yuzhen Xu
- Department of GI Surgery, Xuzhou Central Hospital, Xuzhou, Jiangsu, China
- Yawei Hua
- Department of General Surgery, Henan Cancer Hospital, Zhengzhou, Henan, China
- Chuanlei Wang
- Department of HPB Surgery, The First Bethune Hospital of Jilin University, Changchun, Jilin, China
- Qiyun Li
- Department of Abdominal Surgery, Jiangxi Cancer Hospital, Nanchang, Jiangxi, China
- Jiansheng Liu
- Department of General Surgery, First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
- Mingzhang Li
- Department of General Surgery, Baotou City Central Hospital, Baotou, Inner Mongolia, China
- Yudong Qiu
- Department of Pancreatobiliary Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China
- Buqiang Wu
- Department of General Surgery, Heping Hospital Affiliated to Changzhi Medical College, Changzhi, Shanxi, China
- Jinfang Zheng
- Department of General Surgery, Hainan Provincial People's Hospital, Haikou, Hainan, China
- Haihong Zhu
- Department of General Surgery, Qinghai Provincial People's Hospital, Xining, Qinghai, China
- Kejun Hua
- Department of General Surgery, Yinzhou Hospital Affiliated to Medical School of Ningbo University, Ningbo, Zhejiang, China
- Maolin Yan
- Department of Hepatobiliary Surgery, Fujian Provincial Hospital, Fuzhou, Fujian, China
- Hong Zang
- Department of Hepatobiliary Surgery, The First People's Hospital of Nantong, Nantong, Jiangsu, China
- Xiaoming Ma
- Department of General Surgery, The Second Affiliated Hospital of Suzhou University, Suzhou, Jiangsu, China
- Jian Hong
- Department of General Surgery, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu, China
- DOI
- https://doi.org/10.1136/bmjopen-2020-038634
- Journal volume & issue
-
Vol. 11,
no. 2
Abstract
Introduction Gallbladder cancer (GBC), the sixth most common gastrointestinal tract cancer, poses a significant disease burden in China. However, no national representative data are available on the clinical characteristics, treatment and prognosis of GBC in the Chinese population.Methods and analysis The Chinese Research Group of Gallbladder Cancer (CRGGC) study is a multicentre retrospective registry cohort study. Clinically diagnosed patient with GBC will be identified from 1 January 2008 to December, 2019, by reviewing the electronic medical records from 76 tertiary and secondary hospitals across 28 provinces in China. Patients with pathological and radiological diagnoses of malignancy, including cancer in situ, from the gallbladder and cystic duct are eligible, according to the National Comprehensive Cancer Network 2019 guidelines. Patients will be excluded if GBC is the secondary diagnosis in the discharge summary. The demographic characteristics, medical history, physical examination results, surgery information, pathological data, laboratory examination results and radiology reports will be collected in a standardised case report form. By May 2021, approximately 6000 patient with GBC will be included. The clinical follow-up data will be updated until 5 years after the last admission for GBC of each patient. The study aimed (1) to depict the clinical characteristics, including demographics, pathology, treatment and prognosis of patient with GBC in China; (2) to evaluate the adherence to clinical guidelines of GBC and (3) to improve clinical practice for diagnosing and treating GBC and provide references for policy-makers.Ethics and dissemination The protocol of the CRGGC has been approved by the Committee for Ethics of Xinhua Hospital, Shanghai Jiao Tong University School of Medicine (SHEC-C-2019–085). All results of this study will be published in peer-reviewed journals and presented at relevant conferences.Trial registration number NCT04140552, Pre-results.
