Glucagonoma Syndrome

Abstract

We present the case history of a 45 year old male with a recurrent migratory dermatitis which had been refractory to all modalities of treatment. USG and CT scan of the abdomen revealed a pancreatic tumour with no evidence of metastasis. Surgical resection resulted in a rapid and complete clearing of the cutaneous lesions. Necrolytic migratory erythema is a rare polymorphous eruption which is usually associated with malignant glucagons secreting tumours of the pancreas. It is often the earliest and most specific marker of the underlying malignancy. An awareness of this dermatosis could result in early detection of the associated tumour and resection prior to metastasis, thereby improving the patient’s longterm prognosis.