Halogenated Diterpenes with In Vitro Antitumor Activity from the Red Alga <i>Sphaerococcus coronopifolius</i>
Vangelis Smyrniotopoulos,
Anna Cláudia de Andrade Tomaz,
Maria de Fátima Vanderlei de Souza,
Emídio Vasconcelos Leitão da Cunha,
Robert Kiss,
Véronique Mathieu,
Efstathia Ioannou,
Vassilios Roussis
Affiliations
Vangelis Smyrniotopoulos
Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece
Anna Cláudia de Andrade Tomaz
Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece
Maria de Fátima Vanderlei de Souza
Postgraduate Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-970, PB, Brazil
Emídio Vasconcelos Leitão da Cunha
Postgraduate Program in Bioactive Natural and Synthetic Products, Health Sciences Center, Federal University of Paraíba, João Pessoa 58051-970, PB, Brazil
Robert Kiss
Fonds National de la Recherche Scientifique, 1050 Bruxelles, Belgium
Véronique Mathieu
Department of Pharmacotherapy and Pharmaceutics, Université Libre de Bruxelles, Boulevard du Triomphe, 1050 Brussels, Belgium
Efstathia Ioannou
Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece
Vassilios Roussis
Section of Pharmacognosy and Chemistry of Natural Products, Department of Pharmacy, National and Kapodistrian University of Athens, Panepistimiopolis Zografou, 15771 Athens, Greece
Eight new (1−8) structurally diverse diterpenes featuring five different carbocycles were isolated from the organic extracts of the red alga Sphaerococcus coronopifolius collected from the coastline of the Ionian Sea in Greece. The structures of the new natural products, seven of which were halogenated, and the relative configuration of their stereocenters were determined on the basis of comprehensive spectroscopic analyses, including NMR and HRMS data. Compounds 5 and 8 were found to possess in vitro antitumor activity against one murine and five human cancer cell lines with mean IC50 values 15 and 16 μM, respectively.
