Frontiers in Oncology (Apr 2021)

The Role of miR-640: A Potential Suppressor in Breast Cancer via Wnt7b/β-catenin Signaling Pathway

  • Chun Tang,
  • Chun Tang,
  • Xuehui Wang,
  • Xuehui Wang,
  • Changle Ji,
  • Wenfang Zheng,
  • Yunhe Yu,
  • Xiaochong Deng,
  • Xiqian Zhou,
  • Lin Fang,
  • Lin Fang

DOI
https://doi.org/10.3389/fonc.2021.645682
Journal volume & issue
Vol. 11

Abstract

Read online

In this study, we demonstrated that miR-640 is significantly downregulated in breast cancer (BC) tissues and cell lines. Overexpression of miR-640 inhibited the proliferation and migration of BC in vitro and in vivo, while depletion of miR-640 exhibited the opposite effect. Importantly, miR-640 could directly target Wnt7b, thereby regulating Wnt/β-catenin signaling pathway in BC. In conclusion, miR-640/Wnt7b suppresses BC cells tumorigenesis via Wnt/β-catenin signaling pathway, which might be novel targets for BC targeted therapy.

Keywords