Nature Communications (Mar 2023)
Dietary restriction of cysteine and methionine sensitizes gliomas to ferroptosis and induces alterations in energetic metabolism
- Pavan S. Upadhyayula,
- Dominique M. Higgins,
- Angeliki Mela,
- Matei Banu,
- Athanassios Dovas,
- Fereshteh Zandkarimi,
- Purvi Patel,
- Aayushi Mahajan,
- Nelson Humala,
- Trang T. T. Nguyen,
- Kunal R. Chaudhary,
- Lillian Liao,
- Michael Argenziano,
- Tejaswi Sudhakar,
- Colin P. Sperring,
- Benjamin L. Shapiro,
- Eman R. Ahmed,
- Connor Kinslow,
- Ling F. Ye,
- Markus D. Siegelin,
- Simon Cheng,
- Rajesh Soni,
- Jeffrey N. Bruce,
- Brent R. Stockwell,
- Peter Canoll
Affiliations
- Pavan S. Upadhyayula
- Department of Neurological Surgery, Columbia University Medical Center
- Dominique M. Higgins
- Department of Neurological Surgery, Columbia University Medical Center
- Angeliki Mela
- Department of Pathology and Cell Biology, Columbia University Medical Center
- Matei Banu
- Department of Neurological Surgery, Columbia University Medical Center
- Athanassios Dovas
- Department of Pathology and Cell Biology, Columbia University Medical Center
- Fereshteh Zandkarimi
- Department of Chemistry, Columbia University
- Purvi Patel
- Department of Proteomics and Macromolecular Crystallography, Columbia University Medical Center
- Aayushi Mahajan
- Department of Neurological Surgery, Columbia University Medical Center
- Nelson Humala
- Department of Neurological Surgery, Columbia University Medical Center
- Trang T. T. Nguyen
- Department of Pathology and Cell Biology, Columbia University Medical Center
- Kunal R. Chaudhary
- Department of Radiation Oncology, Columbia University Medical Center
- Lillian Liao
- Department of Neurological Surgery, Columbia University Medical Center
- Michael Argenziano
- Department of Neurological Surgery, Columbia University Medical Center
- Tejaswi Sudhakar
- Department of Neurological Surgery, Columbia University Medical Center
- Colin P. Sperring
- Department of Neurological Surgery, Columbia University Medical Center
- Benjamin L. Shapiro
- Department of Neurological Surgery, Columbia University Medical Center
- Eman R. Ahmed
- Department of Biological Sciences, Columbia University
- Connor Kinslow
- Department of Chemistry, Columbia University
- Ling F. Ye
- Department of Medicine, Columbia University Medical Center
- Markus D. Siegelin
- Department of Pathology and Cell Biology, Columbia University Medical Center
- Simon Cheng
- Department of Chemistry, Columbia University
- Rajesh Soni
- Department of Proteomics and Macromolecular Crystallography, Columbia University Medical Center
- Jeffrey N. Bruce
- Department of Neurological Surgery, Columbia University Medical Center
- Brent R. Stockwell
- Department of Chemistry, Columbia University
- Peter Canoll
- Department of Pathology and Cell Biology, Columbia University Medical Center
- DOI
- https://doi.org/10.1038/s41467-023-36630-w
- Journal volume & issue
-
Vol. 14,
no. 1
pp. 1 – 13
Abstract
Diet intervention is emerging as an option to improve cancer therapy. Here, the authors show that a diet with restrictive cysteine and methionine synergizes with a ferroptosis inducer to increase cell death and survival in glioma preclinical models.
