Metabolic modelling reveals the specialization of secondary replicons for niche adaptation in Sinorhizobium meliloti

George C. diCenzo; Alice Checcucci; Marco Bazzicalupo; Alessio Mengoni; Carlo Viti; Lukasz Dziewit; Turlough M. Finan; Marco Galardini; Marco Fondi

doi:10.1038/ncomms12219

Nature Communications (Jul 2016)

Metabolic modelling reveals the specialization of secondary replicons for niche adaptation in Sinorhizobium meliloti

George C. diCenzo,
Alice Checcucci,
Marco Bazzicalupo,
Alessio Mengoni,
Carlo Viti,
Lukasz Dziewit,
Turlough M. Finan,
Marco Galardini,
Marco Fondi

Affiliations

George C. diCenzo: Department of Biology, McMaster University
Alice Checcucci: Department of Biology, University of Florence
Marco Bazzicalupo: Department of Biology, University of Florence
Alessio Mengoni: Department of Biology, University of Florence
Carlo Viti: Department of Agri-food Production and Environmental Sciences, University of Florence
Lukasz Dziewit: Department of Bacterial Genetics, Institute of Microbiology, Faculty of Biology, University of Warsaw
Turlough M. Finan: Department of Biology, McMaster University
Marco Galardini: EMBL-EBI, Wellcome Trust Genome Campus
Marco Fondi: Department of Biology, University of Florence

DOI: https://doi.org/10.1038/ncomms12219
Journal volume & issue: Vol. 7, no. 1
pp. 1 – 10

Abstract

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The genome of some bacteria consists of two or more chromosomes or replicons. Here, diCenzo et al. integrate genome-scale metabolic modelling and growth data from a collection of mutants of the plant symbiont Sinorhizobium melilotito estimate the fitness contribution of each replicon in three environments.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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