Organocatalytic cycloaddition of alkynylindoles with azonaphthalenes for atroposelective construction of indole-based biaryls

Abstract

There is great interest in methods for catalytic enantioselective construction of axially chiral compounds found in natural products. Here, the authors develop a cycloaddition strategy for atroposelective construction of indole-based biaryls via chiral phosphoric acid-catalysed cycloaddition.