Clinical Ophthalmology (Dec 2019)

Short-Term Changes in Intraocular Pressure After Intravitreal Injection of Bevacizumab for the Treatment of Retinopathy of Prematurity

  • Obata S,
  • Higashiyama T,
  • Imamura T,
  • Kakinoki M,
  • Yanagi T,
  • Maruo Y,
  • Ohji M

Journal volume & issue
Vol. Volume 13
pp. 2445 – 2449

Abstract

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Shumpei Obata,1 Tomoaki Higashiyama,1 Taku Imamura,1 Masashi Kakinoki,1 Takahide Yanagi,2 Yoshihiro Maruo,2 Masahito Ohji1 1Department of Ophthalmology, Shiga University of Medical Science, Otsu, Japan; 2Department of Pediatrics, Shiga University of Medical Science, Otsu, JapanCorrespondence: Shumpei ObataDepartment of Ophthalmology, Shiga University of Medical Science, Seta Tsukinowacho, Otsu, Shiga 520-2192, JapanTel +81-77-548-2276Fax +81-77-548-2279Email [email protected]: To evaluate short-term changes in intraocular pressure after intravitreal injection of bevacizumab for retinopathy of prematurity.Patients and methods: This study was a prospective case-series. Consecutive infants underwent intravitreal injection with bevacizumab for type 1 retinopathy of prematurity at a university hospital. Intraocular pressure was measured with tonometer at baseline, at 1 min, and at 3, 10, 30 and 60 mins after injection.Results: Five patients (four boys) were enrolled in this study. Mean (± standard deviation) intraocular pressure was 8.0 ± 2.4 mmHg (range: 6–11.5 mmHg) just before the intravitreal injection, and the pressures were 19.8 ± 2.8 mmHg (16.4–23.9 mmHg), 14.6 ± 4.4 mmHg (7.6–18.4 mmHg), 11.2 ± 4.2 mmHg (6.4–16.5 mmHg), 9.3 ± 3.5 mmHg (5.8–13.2 mmHg), and 8.2 ± 1.4 mmHg (6.9–10.0 mmHg) at 1 min, 3, 10, 30 and 60 mins after the injection, respectively. Mean intraocular pressure after 1 min was significantly higher than intraocular pressure before injection (p = 0.02). Pressures decreased between 1 min and 3 mins after intravitreal injection, although there was no statistically significant difference between the pressures at those time-points. Intraocular pressures after 3, 10, 30 and 60 mins were not significantly different from the pressure before injection.Conclusion: Intraocular pressure elevation after intravitreal injection of bevacizumab for neonatal infants may be mild, so there may be a limited risk due to intraocular pressure after intraocular injection of bevacizumab for retinopathy of prematurity.Keywords: retinopathy of prematurity, intraocular pressure, bevacizumab

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