Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making

Matthew R. Zanotelli; Aniqua Rahman-Zaman; Jacob A. VanderBurgh; Paul V. Taufalele; Aadhar Jain; David Erickson; Francois Bordeleau; Cynthia A. Reinhart-King

doi:10.1038/s41467-019-12155-z

Nature Communications (Sep 2019)

Energetic costs regulated by cell mechanics and confinement are predictive of migration path during decision-making

Matthew R. Zanotelli,
Aniqua Rahman-Zaman,
Jacob A. VanderBurgh,
Paul V. Taufalele,
Aadhar Jain,
David Erickson,
Francois Bordeleau,
Cynthia A. Reinhart-King

Affiliations

Matthew R. Zanotelli: Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University
Aniqua Rahman-Zaman: Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University
Jacob A. VanderBurgh: Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University
Paul V. Taufalele: Department of Biomedical Engineering, Vanderbilt University
Aadhar Jain: Sibley School of Mechanical and Aerospace Engineering, Cornell University
David Erickson: Sibley School of Mechanical and Aerospace Engineering, Cornell University
Francois Bordeleau: Department of Biomedical Engineering, Vanderbilt University
Cynthia A. Reinhart-King: Nancy E. and Peter C. Meinig School of Biomedical Engineering, Cornell University

DOI: https://doi.org/10.1038/s41467-019-12155-z
Journal volume & issue: Vol. 10, no. 1
pp. 1 – 12

Abstract

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Migrating cells tune their energy utilization in response to their microenvironment, but how cellular energetics direct navigation remains unclear. Here, the authors report that energetic costs for motility, regulated by cell mechanics and confinement, predict the probability of migration choice.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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