Evaluation of Periodontal Parameters in Patients with Early Stage Chronic Lymphocytic Leukemia

Abstract

Objective: To assess periodontal conditions in patients with early stage CLL and to compare it with the periodontal status of age matched healthy controls and to analyze the relationship between periodontal and hematological parameters in CLL patients. Materials and Methods: 60 subjects were examined: 30 patients with CLL Rai 0 (test group) and 30 age-matching healthy individuals (control group). The exclusion criteria were: presence of other systemic disease or condition (e.g. diabetes), history of treatment for periodontitis, use of antibiotics during the last 3 months, use of medications. Socio-demographic data were obtained by means of a questionnaire. Participants with at least 8 teeth underwent a full mouth examination assessing API, PBI, PPD, REC and CAL. Medical data for CLL patients were collected from the patients’ records, while hematological data were obtained from the hemogram. Results: Difference between groups was statistically significant for age, number of teeth and frequency of dental checkups (p0.05), only for REC (F=4.601; p0.05). Conclusion: The results of this study showed that patients with CLL had worse periodontal status compared to healthy subjects. Causal relationship between periodontal and hematological parameters was not proved.

Keywords

• Leukemia, Lymphoid
• Gingivitis
• Periodontitis
• Periodontal Index
• DMF Index