Antiproliferative Activity on Human Colon Adenocarcinoma Cells and In Vitro Antioxidant Effect of Anthocyanin-Rich Extracts from Peels of Species of the <i>Myrtaceae</i> Family
Nayara Simas Frauches,
Júlia Montenegro,
Thuane Amaral,
Joel Pimentel Abreu,
Gabriela Laiber,
Jorge Junior,
Renata Borguini,
Manuela Santiago,
Sidney Pacheco,
Vania Mayumi Nakajima,
Ronoel Godoy,
Anderson Junger Teodoro
Affiliations
Nayara Simas Frauches
Laboratory of Functional Foods, Federal University of Rio de Janeiro State, Avenida Pasteur 296-Urca, 22290-240 Rio de Janeiro, RJ, Brazil
Júlia Montenegro
Laboratory of Functional Foods, Federal University of Rio de Janeiro State, Avenida Pasteur 296-Urca, 22290-240 Rio de Janeiro, RJ, Brazil
Thuane Amaral
Laboratory of Functional Foods, Federal University of Rio de Janeiro State, Avenida Pasteur 296-Urca, 22290-240 Rio de Janeiro, RJ, Brazil
Joel Pimentel Abreu
Laboratory of Functional Foods, Federal University of Rio de Janeiro State, Avenida Pasteur 296-Urca, 22290-240 Rio de Janeiro, RJ, Brazil
Gabriela Laiber
Laboratory of Functional Foods, Federal University of Rio de Janeiro State, Avenida Pasteur 296-Urca, 22290-240 Rio de Janeiro, RJ, Brazil
Jorge Junior
Federal University Fluminense, Mario Santos Braga Street, 30-Centro, 24020-140 Niteroí, RJ, Brazil
Renata Borguini
Embrapa Food Technology, Avenida das Américas, 23020-470 Rio de Janeiro, RJ, Brazil
Manuela Santiago
Embrapa Food Technology, Avenida das Américas, 23020-470 Rio de Janeiro, RJ, Brazil
Sidney Pacheco
Embrapa Food Technology, Avenida das Américas, 23020-470 Rio de Janeiro, RJ, Brazil
Vania Mayumi Nakajima
Federal University Fluminense, Mario Santos Braga Street, 30-Centro, 24020-140 Niteroí, RJ, Brazil
Ronoel Godoy
Embrapa Food Technology, Avenida das Américas, 23020-470 Rio de Janeiro, RJ, Brazil
Anderson Junger Teodoro
Laboratory of Functional Foods, Federal University of Rio de Janeiro State, Avenida Pasteur 296-Urca, 22290-240 Rio de Janeiro, RJ, Brazil
There is a significant indication of the beneficial health effects of fruit rich diets. Fruits of native plant species have noticeably different phytochemicals and bioactive effects. The aim of this work was to characterize and compare the constituents of jabuticaba (Myrciaria jaboticaba, MJ), jamun-berry (Syzygium cumini, SC), and malay-apple (Syzygium malaccense, SM) extracts and their influence on antioxidant activity in vitro and antiproliferative effects on human colon adenocarcinoma cells. According to the results, dried peel powders (DP) have a high anthocyanin content, phenolic compounds, and antioxidant activity when compared to freeze dried extracts (FD). M. jaboticaba dried peel powder extract had a higher total anthocyanin and phenolic compounds content (802.90 ± 1.93 and 2152.92 ± 43.95 mg/100 g, respectively). A reduction in cell viability of HT-29 cells after treatment with M. jaboticaba extracts (DP-MJ and FD-MJ) was observed via MTT assay. Flow cytometry showed that the treatment with the anthocyanin-rich extracts from MJ, SC, and SM had an inhibitory impact on cell development due to G2/M arrest and caused a rise in apoptotic cells in relation to the control group. The findings of this study highlight the potential of peel powders from Myrtaceae fruits as an important source of natural antioxidants and a protective effect against colon adenocarcinoma.
