Scientific Reports (Jul 2021)

Development of custom lead shield and strainer for targeted irradiation for mice in the gamma cell chamber

  • Nurhaslina Hasan,
  • Nur Fatihah Ronny Sham,
  • Muhammad Khalis Abdul Karim,
  • Syed Baharom Syed Ahmad Fuad,
  • Narimah Abdul Hamid Hasani,
  • Effat Omar,
  • Mohammad Johari Ibahim

DOI
https://doi.org/10.1038/s41598-021-93964-5
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 7

Abstract

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Abstract We presented a development of a custom lead shield and mouse strainer for targeted irradiation from the gamma-cell chamber. This study was divided into two parts i.e., to (i) fabricate the shield and strainer from a lead (Pb) and (ii) optimize the irradiation to the mice-bearing tumour model with 2 and 8 Gy absorbed doses. The lead shielding was fabricated into a cuboid shape with a canal on the top and a hole on the vertical side for the beam path. Respective deliveries doses of 28 and 75 Gy from gamma-cell were used to achieve 2 and 8 Gy absorbed doses at the tumour sites.