Journal of Inflammation Research (Feb 2022)

Analysis of the Value of the Blood Urea Nitrogen to Albumin Ratio as a Predictor of Mortality in Patients with Sepsis

  • Han T,
  • Cheng T,
  • Liao Y,
  • Tang S,
  • Liu B,
  • He Y,
  • Gu Z,
  • Lei C,
  • Cao Y,
  • Cao Y

Journal volume & issue
Vol. Volume 15
pp. 1227 – 1235

Abstract

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Tianyong Han,1,* Tao Cheng,1,* Ye Liao,2 Shiyuan Tang,1 Bofu Liu,1 Yarong He,1 Zhihan Gu,1 Chenxi Lei,1 Yuling Cao,3 Yu Cao1 1Emergency Department, West China Hospital of Sichuan University, Chengdu, Sichuan, People’s Republic of China; 2Medical Intensive Care Unit, West China Hospital of Sichuan University, Chengdu, Sichuan, People’s Republic of China; 3Operations Management Department, West China Hospital of Sichuan University, Chengdu, Sichuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yu Cao, Emergency Department, West China Hospital of Sichuan University, 37 Guoxue Lane, Wuhou District, Chengdu, 610041, Sichuan, People’s Republic of China, Tel +028-85422288, Email [email protected]: At present, simple, accurate, and efficient prognostic tools for the evaluation of cases with early-stage sepsis in the emergency department (ED) are lacking. An increased blood urea nitrogen to albumin ratio (BAR) has previously been shown to be a valuable biomarker with predictive utility in several diseases. The relationship between BAR and sepsis patient outcomes, however, is not well-understood. This exploration was thus developed for the exploration of the link between BAR values and the short-term prognosis of cases with sepsis.Methods: This was a retrospective cohort research of sepsis cases admitted to the West China Hospital of Sichuan University ED from July 2015 to June 2016. Laboratory data were collected upon ED admission, and 7-day all-cause mortality was the primary study endpoint. Relationships between BAR values and APACE II and SOFA scores were generated assessed with correlation coefficient heatmaps. Independent risk factors were identified through multivariate analyses, with the curves of receiver operating characteristic (ROC) being employed to gauge the value of BAR as a predictor of the risk of mortality in sepsis cases.Results: In sum, 801 patients participated in the present investigation. BAR values were strongly correlated with APACHE II and SOFA scores. In a multivariate logistic regression assessment, BAR was identified as an independent predictor of mortality among patients with sepsis (HR=1.032, 95% CI: 1.010– 1.055, P=0.004). BAR exhibited an AUC of 0.741 (95% CI: 0.688– 0.793, P< 0.001) when used to predict patient mortality risk, with 5.27 being the optimal BAR cut-off.Conclusion: We found that BAR can be used as a reliable biomarker to predict mortality in patients with sepsis.Keywords: sepsis, blood urea nitrogen-to-albumin ratio, risk factors, prognosis

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