International Journal of Nanomedicine (May 2021)
Drug Delivery to the Bone Microenvironment Mediated by Exosomes: An Axiom or Enigma
Abstract
Sasmita Samal,1,2 Pratigyan Dash,1,2 Mamoni Dash1 1Institute of Life Sciences, Nalco Square, Bhubaneswar, Odisha, 751023, India; 2School of Biotechnology, Kalinga Institute of Industrial Technology (KIIT) University, Bhubaneswar, Odisha, 751024, IndiaCorrespondence: Mamoni DashInstitute of Life Sciences, Bhubaneswar, Odisha, IndiaEmail [email protected]: The increasing incidence of bone-related disorders is causing a burden on the clinical scenario. Even though bone is one of the tissues that possess tremendous regenerative potential, certain bone anomalies need therapeutic intervention through appropriate delivery of a drug. Among several nanosystems and biologics that offer the potential to contribute towards bone healing, the exosomes from the class of extracellular vesicles are outstanding. Exosomes are extracellular nanovesicles that, apart from the various advantages, are standing out of the crowd for their ability to conduct cellular communication. The internal cargo of the exosomes is leading to its potential use in therapeutics. Exosomes are being unraveled in terms of the mechanism as well as application in targeting various diseases and tissues. Through this review, we have tried to understand and review all that is already established and the gap areas that still exist in utilizing them as drug delivery vehicles targeting the bone. The review highlights the potential of the exosomes towards their contribution to the drug delivery scenario in the bone microenvironment. A comparison of the pros and cons of exosomes with other prevalent drug delivery systems is also done. A section on the patents that have been generated so far from this field is included.Keywords: drug delivery, bone diseases, exosomes, nanosystems, RANK-RANKL pathway, exosome-liposome hybrid
