World Journal of Emergency Surgery (Feb 2009)

Molecular mechanisms of traumatic brain injury: the missing link in management

  • Burnstein Rowan M,
  • Goon Serena SH,
  • Veenith Tonny

DOI
https://doi.org/10.1186/1749-7922-4-7
Journal volume & issue
Vol. 4, no. 1
p. 7

Abstract

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Abstract Head injury is common, sometimes requires intensive care unit admission, and is associated with significant mortality and morbidity. A gap still remains in the understanding of the molecular mechanism of this condition. This review is aimed at providing a general overview of the molecular mechanisms involved in traumatic brain injury to a busy clinician. It will encompass the pathophysiology in traumatic brain injury including apoptosis, the role of molecules and genes, and a brief mention of possible pharmacological therapies.