Stroke and Vascular Neurology ()
Associations of polygenic risk scores with risks of stroke and its subtypes in Chinese
- ,
- Yu Guo,
- Derrick Bennett,
- Huaidong Du,
- Liming Li,
- Robert Clarke,
- Zhengming Chen,
- Junshi Chen,
- Ruying Hu,
- Kaixu Xie,
- Min Yu,
- Qiang Sun,
- Jun Zhang,
- Ling Yang,
- Shuo Zhang,
- Dianjianyi Sun,
- Hao Wang,
- Hua Zhang,
- Lingli Chen,
- Hao Zhang,
- Liang Cheng,
- Chao Liu,
- Hui Zhang,
- Fang Liu,
- Xin Xu,
- Wei Jiang,
- Tao Wang,
- Rory Collins,
- Jun Lv,
- Richard Peto,
- Robin Walters,
- Daniel Avery,
- Ruth Boxall,
- Yumei Chang,
- Yiping Chen,
- Simon Gilbert,
- Alex Hacker,
- Michael Holmes,
- Christiana Kartsonaki,
- Rene Kerosi,
- Kuang Lin,
- Iona Millwood,
- Qunhua Nie,
- Paul Ryder,
- Sam Sansome,
- Dan Schmidt,
- Rajani Sohoni,
- Becky Stevens,
- Iain Turnbull,
- Lin Wang,
- Neil Wright,
- Xiaoming Yang,
- Xiao Han,
- Can Hou,
- Pei Pei,
- Canqing Yu,
- Zengchang Pang,
- Ruqin Gao,
- Shanpeng Li,
- Shaojie Wang,
- Yongmei Liu,
- Ranran Du,
- Yajing Zang,
- Xiaocao Tian,
- Yaoming Zhai,
- Feng Ning,
- Xiaohui Sun,
- Silu Lv,
- Junzheng Wang,
- Yanjie Li,
- Quan Kang,
- Zhendong Guo,
- Ming Wu,
- Yonglin Zhou,
- Jinyi Zhou,
- Ran Tao,
- Jie Yang,
- Yihe Hu,
- Yan Lu,
- Liangcai Ma,
- Aiyu Tang,
- Jianrong Jin,
- Liuping Wei,
- Liyuan Zhou,
- Yulu Qin,
- Xianping Wu,
- Ningmei Zhang,
- Xiaofang Chen,
- Jiaqiu Liu,
- Xiaolan Ren,
- Enke Mao,
- Xiaoping Wang,
- Shixian Feng,
- Huarong Sun,
- Pan He,
- Xukui Zhang,
- Zhongxi Fu,
- Libo Zhang,
- Jingchao Liu,
- Andri Iona,
- Paul Sherliker,
- Wei Hou,
- Xiangyang Zheng,
- Yilei Li,
- Huimei Li,
- Yun Liu,
- Ningyu Chen,
- Caixia Dong,
- Xi Zhang,
- Lei Fan,
- Donghui Jin,
- Wei Sun,
- Jian Su,
- Mike Hill,
- Feifei Li,
- Shukuan Wu,
- Jian Lan,
- Sisi Wang,
- Kai Kang,
- Xiao Li,
- Pang Yao,
- Songchun Yang,
- Shichun Yan,
- Huilin Liu Li Yin,
- Chi Wang,
- Ka Hung Chan,
- Lifang Zhou,
- Xiaoyu Chang,
- Mohsen Mazidi,
- Mei Lin,
- Yuanjie Pang,
- Iona Y Millwood,
- Xiaoming Cui,
- Yuan Cao,
- Xia Wu,
- Pek Kei Im,
- Xiaoyi Zhang,
- Dong Sun,
- Robin G Walters,
- Zhijia Sun,
- Sushila Burgess,
- Sue Burgess,
- Johnathan Clarke,
- Ahmed Edris Mohamed,
- Zammy Fairhurst-Hunter,
- Hannah Fry,
- Maria Kakkoura,
- Sam Morris,
- Alfred Pozarickij,
- Saredo Said,
- Qingmei Xia,
- Haiping Duan,
- Zhenyuan Wu,
- Huiming Luo,
- Tingting Ou,
- Zhenzhen Lu,
- Changping Xie,
- Tingping Zhu,
- Mingqiang Yuan,
- Faqing Chen,
- Huizi Tian,
- Dun Shen,
- Xiaojun Li,
- Jianwei Chen,
- Yuan Peng,
- Chan Qu
Affiliations
- University of Pennsylvania, Rheumatology, Philadelphia, United States of America
- Yu Guo
- State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China
- Derrick Bennett
- Nuffield Department of Population Health, University of Oxford, Oxford, UK
- Huaidong Du
- Nuffield Department of Population Health, University of Oxford, Oxford, Oxfordshire, UK
- Liming Li
- professor
- Robert Clarke
- Clinical Trial Service Unit and Epidemiological Studies, NDPH, University of Oxford, Oxford, UK
- Zhengming Chen
- professor
- Junshi Chen
- professor
- Ruying Hu
- Department of NCDs Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China
- Kaixu Xie
- 3 Tongxiang Center for Disease Control and Prevention, Jiaxing, China
- Min Yu
- Department of NCDs Control and Prevention, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, Zhejiang, China
- Qiang Sun
- Shandong University School of Public Health, Jinan, Shandong, China
- Jun Zhang
- 1 Department of General Surgery, Pancreatic Disease Center, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People`s Republic of China
- Ling Yang
- 4Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK
- Shuo Zhang
- 1 Shanghai Ji Ai Genetics & IVF Institute, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China
- Dianjianyi Sun
- PhD candidate
- Hao Wang
- Department of Pharmacy, Nanjing Drum Tower Hospital, Nanjing, Jiangsu, China
- Hua Zhang
- Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment, Zhuhai Institute of Translational Medicine, Zhuhai People`s Hospital Affiliated with Jinan University, Jinan University, Zhuhai, Guangdong, China
- Lingli Chen
- 3 Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, China
- Hao Zhang
- Department of Thoracic Surgery, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
- Liang Cheng
- Pathology and Laboratory Medicine, Brown University Warren Alpert Medical School and Lifespan Academic Medical Center, Providence, Rhode Island, USA
- Chao Liu
- Department of Neonatal Surgery, Children’s Hospital of Capital Institute of Pediatrics, Capital Institute of Pediatrics, Beijing, China
- Hui Zhang
- 4 Division of Biostatistics, Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA
- Fang Liu
- 12 Cardiovascular Center, Children`s Hospital of Fudan University, National Children`s Medical Center, Shanghai, China
- Xin Xu
- 1 Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China
- Wei Jiang
- 1 Obstetrics and Gynecology Hospital, Fudan University, Shanghai, China
- Tao Wang
- 2 Department of Orthopaedics, Kunming Municipal Hospital of Traditional Chinese Medicine, Kunming, China
- Rory Collins
- Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
- Jun Lv
- 2Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China
- Richard Peto
- Clinical Trial Service Unit & Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK
- Robin Walters
- Daniel Avery
- Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK
- Ruth Boxall
- Yumei Chang
- Yiping Chen
- College of Nursing, Shanxi Medical University, Taiyuan, Shanxi, China
- Simon Gilbert
- Alex Hacker
- Michael Holmes
- Aff2 grid.421831.dSangamo Biosciences Richmond CA USA
- Christiana Kartsonaki
- International Severe Acute Respiratory and emerging Infection Consortium (ISARIC), Pandemic Sciences Institute, University of Oxford, Oxford, UK
- Rene Kerosi
- Kuang Lin
- Iona Millwood
- Qunhua Nie
- Paul Ryder
- Sam Sansome
- Dan Schmidt
- Rajani Sohoni
- Becky Stevens
- Iain Turnbull
- clinical research fellow
- Lin Wang
- 4 Beijing Airdoc Technology Co., Ltd, Beijing, China
- Neil Wright
- 2 Paediatric Endocrinology & Diabetes, Sheffield Children`s Hospital, Sheffield, UK
- Xiaoming Yang
- Image-Guided Bio-Molecular Intervention Research and Section of Vascular and Interventional Radiology, Department of Radiology, University of Washington School of Medicine, Seattle, Washington, USA
- Xiao Han
- 1 School of Health Service Management, Anhui Medical University, Hefei, Anhui, China
- Can Hou
- Pei Pei
- 3Peking University Center for Public Health and Epidemic Preparedness and Response, Beijing, China
- Canqing Yu
- assistant professor
- Zengchang Pang
- Ruqin Gao
- Shanpeng Li
- Shaojie Wang
- Yongmei Liu
- 44Division of Public Health Sciences, Department of Epidemiology and Prevention, Wake Forest University, Winston-Salem, North Carolina, USA
- Ranran Du
- Yajing Zang
- 6 Qingdao Centre for Disease Control and Prevention, Qingdao, Shandong, China
- Xiaocao Tian
- Yaoming Zhai
- Feng Ning
- Xiaohui Sun
- 2School of Public Health, Zhejiang Chinese Medical University, China
- Silu Lv
- Junzheng Wang
- Yanjie Li
- investigator
- Quan Kang
- Zhendong Guo
- Ming Wu
- 1 Department of Non-communicable Chronic Disease Control, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China
- Yonglin Zhou
- 1 Jiangsu Province Center for Disease Control and Prevention, Nanjing, China
- Jinyi Zhou
- Department of Epidemiology, Nanjing Medical University, Nanjing, China
- Ran Tao
- Aff2 SYZ Cell Therapy Co. Peoples Republic of China
- Jie Yang
- 1 Department of Non-communicable Chronic Disease Control, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China
- Yihe Hu
- 5Suzhou Municipal Centre for Disease Control and Prevention, China
- Yan Lu
- 4 Department of Chronic Disease Prevention and Control, Suzhou Center for Disease Prevention and Control, Suzhou, China
- Liangcai Ma
- Aiyu Tang
- Jianrong Jin
- 4 Wuzhong Center for Disease Control & Prevention, Suzhou, China
- Liuping Wei
- Liyuan Zhou
- 7 Liu Zhou Center for Disease Prevention and Control, Liuzhou, China
- Yulu Qin
- Xianping Wu
- Department of Chronic Noncommunicable Disease Control and Prevention, Sichuan Center for Disease Control and Prevention, Chengdu, Sichuan, China
- Ningmei Zhang
- Department of Chronic and Non-communicable Disease Control and Prevention, Sichuan Center for Disease Control and Prevention, Chengdu, Sichuan, China
- Xiaofang Chen
- 5 Department of Epidemiology and Health Statistics, Public Health School, Chengde Medical College, Chengde, China
- Jiaqiu Liu
- Xiaolan Ren
- 4Gansu Center for Disease Control and Prevention, Lanzhou, China
- Enke Mao
- Xiaoping Wang
- Department of Psychiatry, National Clinical Research Centre for Mental Disorders, The Second Xiangya Hospital, Central South University, Changsha, China
- Shixian Feng
- Huarong Sun
- Pan He
- Xukui Zhang
- Zhongxi Fu
- Libo Zhang
- 1 COVID-19 Research Center, Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu 210002, China
- Jingchao Liu
- 4 Wuzhong Center for Disease Control & Prevention, Suzhou, China
- Andri Iona
- 1 Clinical Trial Service Unit and Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK
- Paul Sherliker
- Wei Hou
- chief
- Xiangyang Zheng
- Yilei Li
- Huimei Li
- Yun Liu
- Department of Rheumatology, Zhongshan Hospital, Fudan University, Shanghai, China
- Ningyu Chen
- Caixia Dong
- Xi Zhang
- Affliated Hospital of Guizhou Medical University, Guiyang, China
- Lei Fan
- Donghui Jin
- 7 Hunan Provincial Center for Disease Control and Prevention, Changsha, China
- Wei Sun
- 1 Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, and Department of Orthopedic Surgery of the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China
- Jian Su
- Guangdong Lung Cancer Institute, Guangdong Provincial People`s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China
- Mike Hill
- Feifei Li
- 4 School of Computing, University of Utah, Salt Lake City, Utah, USA
- Shukuan Wu
- Jian Lan
- Sisi Wang
- 5 Non-Communicable Disease Prevention and Control Department, Liuzhou CDC, Liuzhou, Guangxi, China
- Kai Kang
- Aff306 grid.239578.20000000106754725Taussig Cancer Institute, Cleveland Clinic Cleveland OH USA
- Xiao Li
- Department of Gastroenterology and Hepatology, Sichuan University West China Hospital, Chengdu, Sichuan, China
- Pang Yao
- Songchun Yang
- 1 Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Centre, Beijing, China
- Shichun Yan
- 5 NCDs Prevention and Control Department, Heilongjiang Centre for Disease Control and Prevention, Harbin, Heilongjiang, China
- Huilin Liu Li Yin
- Chi Wang
- Department of Cardiology, Chinese PLA General Hospital, Beijing, China
- Ka Hung Chan
- Lifang Zhou
- Occupational Health and Radiation Protection Department, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China
- Xiaoyu Chang
- Sichuan Provincial Center for Disease Control and Prevention, Chengdu, China
- Mohsen Mazidi
- Department of Twin Research, King`s College London, London, UK
- Mei Lin
- State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China
- Yuanjie Pang
- assistant professor
- Iona Y Millwood
- 4Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK
- Xiaoming Cui
- State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Academy of Military Medical Sciences, Beijing, China
- Yuan Cao
- Department of Gynecology and Obstetrics
- Xia Wu
- Department of Hematology, West China Hospital, Sichuan University, Chengdu, Sichuan, China
- Pek Kei Im
- 1Department of Anthropology, University College London, London, UK
- Xiaoyi Zhang
- 1Zhongshan Hospital
- Dong Sun
- Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China
- Robin G Walters
- 4Medical Research Council Population Health Research Unit at the University of Oxford, Oxford, UK
- Zhijia Sun
- Department of Epidemiology & Biostatistics, School of Public Health, Peking University, Beijing, China
- Sushila Burgess
- Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, Oxford, UK
- Sue Burgess
- Johnathan Clarke
- Ahmed Edris Mohamed
- Zammy Fairhurst-Hunter
- Hannah Fry
- Maria Kakkoura
- Sam Morris
- Alfred Pozarickij
- Saredo Said
- Qingmei Xia
- Haiping Duan
- Zhenyuan Wu
- Huiming Luo
- Tingting Ou
- Zhenzhen Lu
- Changping Xie
- Tingping Zhu
- Mingqiang Yuan
- Faqing Chen
- Huizi Tian
- Dun Shen
- Xiaojun Li
- Jianwei Chen
- Yuan Peng
- Chan Qu
Abstract
Background and purpose Previous studies, mostly focusing on the European population, have reported polygenic risk scores (PRSs) might achieve risk stratification of stroke. We aimed to examine the association strengths of PRSs with risks of stroke and its subtypes in the Chinese population.Methods Participants with genome-wide genotypic data in China Kadoorie Biobank were split into a potential training set (n=22 191) and a population-based testing set (n=72 150). Four previously developed PRSs were included, and new PRSs for stroke and its subtypes were developed. The PRSs showing the strongest association with risks of stroke or its subtypes in the training set were further evaluated in the testing set. Cox proportional hazards regression models were used to estimate the association strengths of different PRSs with risks of stroke and its subtypes (ischaemic stroke (IS), intracerebral haemorrhage (ICH) and subarachnoid haemorrhage (SAH)).Results In the testing set, during 872 919 person-years of follow-up, 8514 incident stroke events were documented. The PRSs of any stroke (AS) and IS were both positively associated with risks of AS, IS and ICH (p<0.05). The HR for per SD increment (HRSD) of PRSAS was 1.10 (95% CI 1.07 to 1.12), 1.10 (95% CI 1.07 to 1.12) and 1.13 (95% CI 1.07 to 1.20) for AS, IS and ICH, respectively. The corresponding HRSD of PRSIS was 1.08 (95% CI 1.06 to 1.11), 1.08 (95% CI 1.06 to 1.11) and 1.09 (95% CI 1.03 to 1.15). PRSICH was positively associated with the risk of ICH (HRSD=1.07, 95% CI 1.01 to 1.14). PRSSAH was not associated with risks of stroke and its subtypes. The addition of current PRSs offered little to no improvement in stroke risk prediction and risk stratification.Conclusions In this Chinese population, the association strengths of current PRSs with risks of stroke and its subtypes were moderate, suggesting a limited value for improving risk prediction over traditional risk factors in the context of current genome-wide association study under-representing the East Asian population.
