Iron metabolism in tuberculosis and iron-containing chemotherapeutic drugs for its treatment

Abstract

This review included the Russian and international articles on the iron metabolism in tuberculosis and the use of iron-containing drugs in the treatment of tuberculosis over the past 20 years. The main topics covered by the researchers include the features of iron metabolism in mycobacteria, the varieties and pathogenesis of anemia that can develop in tuberculosis: iron deficiency (absolute iron deficiency), associated with a chronic disease (relative iron deficiency) or drug-induced anemia (siderohrestic, hemolytic, aplastic). The possible correction of treatment regimens for tuberculosis is analyzed with the introduction of a complex compound of iron with isoniazid in order to reduce undesirable adverse reactions to isoniazid . The literature search for this review was performed using the RSCI, CyberLeninka, Scopus, Web of Science, MedLine, PubMed databases.

Keywords

• tuberculosis
• mycobacterium
• iron metabolism
• isoniazid
• phenazide