Distinct homeostatic modulations stabilize reduced postsynaptic receptivity in response to presynaptic DLK signaling

Abstract

Dual leucine zipper kinase (DLK) activates an intrinsic neuronal response to injury and is also implicated in neurodegeneration. Here, Goel and Dickman characterize how postsynaptic targets adapt to presynaptic DLK signaling through a downregulation of synaptic strength.