Experimental Antiviral Therapeutic Studies for Human Rhinovirus Infections

Abstract

James A Coultas, 1 John Cafferkey, 2 Patrick Mallia, 1 Sebastian L Johnston 1 1National Heart and Lung Institute, Imperial College London, London, UK; 2Respiratory Medicine, St Mary’s Hospital, Imperial College Healthcare Foundation Trust, London, UKCorrespondence: James A CoultasNational Heart and Lung Institute, Imperial College London, Norfolk Place, London, W2 1PG, UKEmail [email protected]: Rhinovirus infection is common and usually causes mild, self-limiting upper respiratory tract symptoms. Rhinoviruses can cause exacerbation of chronic respiratory diseases, such as asthma or chronic obstructive pulmonary disease, leading to a significant burden of morbidity and mortality. There has been a great deal of progress in efforts to understand the immunological basis of rhinovirus infection. However, despite a number of in vitro and in vivo attempts, there have been no effective treatments developed. This review article summarises the up to date virological and immunological understanding of these infections. We discuss the challenges researchers face, and key solutions, in their work to investigate potential therapies including in vivo rhinovirus challenge studies. Finally, we explore past and present experimental therapeutic strategies employed in the treatment of rhinovirus infections and highlight promising areas of future work.Keywords: antiviral agents, respiratory tract infections, rhinovirus, therapeutics

Keywords

• antiviral agents
• respiratory tract infections
• rhinovirus
• therapeutics