αvβ3 Integrin induces partial EMT independent of TGF-β signaling

Yoshinobu Kariya; Midori Oyama; Takato Suzuki; Yukiko Kariya

doi:10.1038/s42003-021-02003-6

Communications Biology (Apr 2021)

αvβ3 Integrin induces partial EMT independent of TGF-β signaling

Yoshinobu Kariya,
Midori Oyama,
Takato Suzuki,
Yukiko Kariya

Affiliations

Yoshinobu Kariya: Department of Biochemistry, Fukushima Medical University School of Medicine
Midori Oyama: Department of Biochemistry, Fukushima Medical University School of Medicine
Takato Suzuki: Laboratory Animal Research Center, Fukushima Medical University School of Medicine
Yukiko Kariya: Department of Biochemistry, Fukushima Medical University School of Medicine

DOI: https://doi.org/10.1038/s42003-021-02003-6
Journal volume & issue: Vol. 4, no. 1
pp. 1 – 11

Abstract

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Kariya, Oyama et al. propose that αvβ3 can drive a partial EMT phenotype characterized by maintained E-cadherin expression and upregulation of mesenchymal markers. This hybrid EMT state is independent of TGF-β1 signaling and characterised by increased migration, invasion, tumor cell proliferation, stemness and metastatic capacity.

Published in Communications Biology

ISSN: 2399-3642 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science: Biology (General)
Website: https://www.nature.com/commsbio/

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