NTF3 Correlates With Prognosis and Immune Infiltration in Hepatocellular Carcinoma

Rongqiang Liu; Rongqiang Liu; Rongqi Li; Haoyuan Yu; Jianrong Liu; Shiyang Zheng; Yang Li; Linsen Ye

doi:10.3389/fmed.2021.795849

Frontiers in Medicine (Dec 2021)

NTF3 Correlates With Prognosis and Immune Infiltration in Hepatocellular Carcinoma

Rongqiang Liu,
Rongqiang Liu,
Rongqi Li,
Haoyuan Yu,
Jianrong Liu,
Shiyang Zheng,
Yang Li,
Linsen Ye

Affiliations

Rongqiang Liu: Department of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Rongqiang Liu: Department of Hepatobiliary Surgery, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Rongqi Li: Department of Hepatobiliary Surgery, Foshan Hospital of Traditional Chinese Medical, Foshan, China
Haoyuan Yu: Department of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Jianrong Liu: Surgical and Transplant Intensive Care Unit of The Third Affiliated Hospital, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Shiyang Zheng: Department of Breast Surgery, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China
Yang Li: Department of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China
Linsen Ye: Department of Hepatic Surgery and Liver Transplantation Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China

DOI: https://doi.org/10.3389/fmed.2021.795849
Journal volume & issue: Vol. 8

Abstract

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Background: The potential role of Neurotrophic factor-3(NTF3) in liver cancer is unknown. Therefore, we aimed to explore the clinical value of NTF3 in hepatocellular carcinoma (HCC).Methods: We used a variety of databases to analyze the expression, relationship with prognosis and immune significance of NTF3 in liver cancer through bioinformatics.Results: NTF3 was low expressed in HCC and was an independent prognostic factor in patients with HCC. CIBERSORT analysis indicated that NTF3 expression was positively correlated with CD4+ cells, mast cells, NK cells, macrophages and B cells in the tumor microenvironment. Furthermore, we found that NTF3 expression was negatively correlated with the immune checkpoints PD-L1, TIGIT and TIM-3. Functional network analysis revealed that NTF3 regulates HCC progression through a variety of cancer-related kinases, transcription factors and signaling pathways.Conclusions: We demonstrate that NTF3 correlates with prognosis and immune infiltration in HCC.

Published in Frontiers in Medicine

ISSN: 2296-858X (Online)
Publisher: Frontiers Media S.A.
Country of publisher: Switzerland
LCC subjects: Medicine: Medicine (General)
Website: http://www.frontiersin.org/journals/medicine

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Abstract

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