A polytherapy based approach to combat antimicrobial resistance using cubosomes

Xiangfeng Lai; Mei-Ling Han; Yue Ding; Seong Hoong Chow; Anton P. Le Brun; Chun-Ming Wu; Phillip J. Bergen; Jhih-hang Jiang; Hsien-Yi Hsu; Benjamin W. Muir; Jacinta White; Jiangning Song; Jian Li; Hsin-Hui Shen

doi:10.1038/s41467-022-28012-5

Nature Communications (Jan 2022)

A polytherapy based approach to combat antimicrobial resistance using cubosomes

Xiangfeng Lai,
Mei-Ling Han,
Yue Ding,
Seong Hoong Chow,
Anton P. Le Brun,
Chun-Ming Wu,
Phillip J. Bergen,
Jhih-hang Jiang,
Hsien-Yi Hsu,
Benjamin W. Muir,
Jacinta White,
Jiangning Song,
Jian Li,
Hsin-Hui Shen

Affiliations

Xiangfeng Lai: Department of Materials Science and Engineering, Faculty of Engineering, Monash University
Mei-Ling Han: Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University
Yue Ding: Department of Materials Science and Engineering, Faculty of Engineering, Monash University
Seong Hoong Chow: Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University
Anton P. Le Brun: Australian Centre for Neutron Scattering, Australian Nuclear Science and Technology Organisation
Chun-Ming Wu: Australian Centre for Neutron Scattering, Australian Nuclear Science and Technology Organisation
Phillip J. Bergen: Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University
Jhih-hang Jiang: Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University
Hsien-Yi Hsu: School of Energy and Environment & Department of Materials Science and Engineering, City University of Hong Kong
Benjamin W. Muir: CSIRO Manufacturing
Jacinta White: CSIRO Manufacturing
Jiangning Song: Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University
Jian Li: Infection and Immunity Program, Monash Biomedicine Discovery Institute and Department of Microbiology, Monash University
Hsin-Hui Shen: Department of Materials Science and Engineering, Faculty of Engineering, Monash University

DOI: https://doi.org/10.1038/s41467-022-28012-5
Journal volume & issue: Vol. 13, no. 1
pp. 1 – 12

Abstract

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An increasing prevalence of Gram-negative bacteria increases the interest in nanotherapies to treat antibiotic resistance. Here, the authors examine the antimicrobial activity of polymyxin-loaded cubosomes and explore a polytherapy treatment of pathogens with cubosomes in combination with polymyxin.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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