Nature Communications (May 2020)

Endothelin-1 signaling maintains glial progenitor proliferation in the postnatal subventricular zone

  • Katrina L. Adams,
  • Giulia Riparini,
  • Payal Banerjee,
  • Marjolein Breur,
  • Marianna Bugiani,
  • Vittorio Gallo

DOI
https://doi.org/10.1038/s41467-020-16028-8
Journal volume & issue
Vol. 11, no. 1
pp. 1 – 17

Abstract

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Endothelin-1 (ET-1) is a vasoconstrictor molecule that is also present in the developing and injured CNS. Here the authors show that ET-1 is present in the postnatal subventricular zone and acts to regulate maintenance and proliferation of radial glial cells and oligodendrocyte progenitor cells.