Endothelin-1 signaling maintains glial progenitor proliferation in the postnatal subventricular zone

Katrina L. Adams; Giulia Riparini; Payal Banerjee; Marjolein Breur; Marianna Bugiani; Vittorio Gallo

doi:10.1038/s41467-020-16028-8

Nature Communications (May 2020)

Endothelin-1 signaling maintains glial progenitor proliferation in the postnatal subventricular zone

Katrina L. Adams,
Giulia Riparini,
Payal Banerjee,
Marjolein Breur,
Marianna Bugiani,
Vittorio Gallo

Affiliations

Katrina L. Adams: Center for Neuroscience Research, Children’s National Research Institute, Children’s National Hospital
Giulia Riparini: Center for Neuroscience Research, Children’s National Research Institute, Children’s National Hospital
Payal Banerjee: Children’s National Research Institute Bioinformatics Unit, Children’s National Hospital
Marjolein Breur: Department of Child Neurology, VU University Medical Center
Marianna Bugiani: Department of Pathology, VU University Medical Center
Vittorio Gallo: Center for Neuroscience Research, Children’s National Research Institute, Children’s National Hospital

DOI: https://doi.org/10.1038/s41467-020-16028-8
Journal volume & issue: Vol. 11, no. 1
pp. 1 – 17

Abstract

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Endothelin-1 (ET-1) is a vasoconstrictor molecule that is also present in the developing and injured CNS. Here the authors show that ET-1 is present in the postnatal subventricular zone and acts to regulate maintenance and proliferation of radial glial cells and oligodendrocyte progenitor cells.

Published in Nature Communications

ISSN: 2041-1723 (Online)
Publisher: Nature Portfolio
Country of publisher: United Kingdom
LCC subjects: Science
Website: https://www.nature.com/ncomms/

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