The effect of resistance training on the expression relationship between IL-6 from skeletal muscle with Cathepsin B and FNDC5 from the hippocampus in rats with glioblastoma multiforme

Abstract

Glioblastoma multiforme (GBM) is a highly aggressive malignant brain tumor with limited treatment options and a poor prognosis. In this study, we aimed to explore the potential effects of resistance training (RT) on the expression relationship between interleukin-6 (IL-6) from skeletal muscle and its interaction with Cathepsin B and Fibronectin type III domain-containing protein 5 (FNDC5) in the hippocampus of rats with GBM. To investigate the role of RT in GBM, we conducted a study using a rat model. By conducting a 4-week RT intervention (three days/week, 30 to 100% of body weight, 3 sets with 4 repetitions/session) and analyzing the expression levels of gastrocnemius muscle IL-6, hippocampal Cathepsin B, and FNDC5, we aimed to shed light on the potential impact of this RT modality on GBM progression. The results showed that GBM induced a significant decrease in gastrocnemius muscle IL-6, hippocampal FNDC5, and Cathepsin B gene expressions that were adjusted by RT. It means that there are significant increases in the GBM+RT group when compared to GBM. There were significant and positive correlations between variables (gastrocnemius muscle IL-6, hippocampal FNDC5, and hippocampal Cathepsin B gene expressions) which led to tissue crosstalk. In conclusion, this study contributes to our understanding of the molecular mechanisms associated with GBM, revealing potential avenues for future therapeutic interventions. RT may serve as a promising approach to modulate the expression relationship between IL-6, Cathepsin B, and FNDC5, offering a potential strategy for improving outcomes in GBM.

Keywords

• brain tumor
• cathepsin b
• fndc5
• glioblastoma multiforme
• resistance training
• tissue crosstalk